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10.1128/MCB.00004-16 http://scihub22266oqcxt.onion/10.1128/MCB.00004-16 C4859695!4859695 !26976639     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26976639 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity |pdf=|usr=}}{{26976639 }} gab.com Text Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26976639 #FOAvip RNA polymerase I-mediated rRNA production is a key determinant of cell growth. Despite extensive studies, the signaling pathways that control RNA polymerase I-mediated rRNA production are not well understood. Here we provide original evidence showing that RNA polymerase I transcriptional activity is tightly controlled by integrin signaling. Furthermore, we show that a signaling axis consisting of focal adhesion kinase (FAK), Src, phosphatidylinositol 3-kinase (PI3K), Akt, and mTOR mediates the effect of integrin signaling on rRNA transcription. Additionally, we show that in kindlin-2 knockout mouse embryonic fibroblasts, overactivation of Ras, Akt, and Src can successfully rescue the defective RNA polymerase I activity induced by the loss of kindlin-2. Finally, through experiments with inhibitors of FAK, Src, and PI3K and rescue experiments in MEFs, we found that the FAK/Src/PI3K/Akt signaling pathway to control rRNA transcription is linear. Collectively, these studies reveal, for the first time, a pivotal role of integrin signaling in regulation of RNA polymerase I transcriptional activity and shed light on the downstream signaling axis that participates in regulation of this key aspect of cell growth. Twit Text FOAVip Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26976639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26976639 #FOAvip English Wikipedia <ref>{{Cite pmid|26976639 }}</ref> Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity #MMPMID26976639 Wu C ; You J ; Fu J ; Wang X ; Zhang Y Mol Cell Biol 2016[May]; 36 (10 ): 1555-68 PMID26976639 show ga RNA polymerase I-mediated rRNA production is a key determinant of cell growth. Despite extensive studies, the signaling pathways that control RNA polymerase I-mediated rRNA production are not well understood. Here we provide original evidence showing that RNA polymerase I transcriptional activity is tightly controlled by integrin signaling. Furthermore, we show that a signaling axis consisting of focal adhesion kinase (FAK), Src, phosphatidylinositol 3-kinase (PI3K), Akt, and mTOR mediates the effect of integrin signaling on rRNA transcription. Additionally, we show that in kindlin-2 knockout mouse embryonic fibroblasts, overactivation of Ras, Akt, and Src can successfully rescue the defective RNA polymerase I activity induced by the loss of kindlin-2. Finally, through experiments with inhibitors of FAK, Src, and PI3K and rescue experiments in MEFs, we found that the FAK/Src/PI3K/Akt signaling pathway to control rRNA transcription is linear. Collectively, these studies reveal, for the first time, a pivotal role of integrin signaling in regulation of RNA polymerase I transcriptional activity and shed light on the downstream signaling axis that participates in regulation of this key aspect of cell growth. |Animals [MESH] |Cell Line [MESH] |Cell Proliferation [MESH] |Fibroblasts/cytology/metabolism [MESH] |Focal Adhesion Kinase 1/metabolism [MESH] |Integrins/*metabolism [MESH] |Mice [MESH] |Phosphatidylinositol 3-Kinase/*metabolism [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |RNA Polymerase I/*metabolism [MESH] |RNA, Ribosomal/*genetics [MESH] |Signal Transduction [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Transcription, Genetic [MESH]Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Contr(epmc).pdf DeepDyve Pubget Overpricing