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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transl+Res
2016 ; 8
(3
): 1593-600
Nephropedia Template TP
gab.com Text
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English Wikipedia
The combination of tacrolimus and entecavir improves the remission of
HBV-associated glomerulonephritis without enhancing viral replication
#MMPMID27186284
Wang L
; Ye Z
; Liang H
; Zhang B
; Xu L
; Feng Z
; Liu S
; Shi W
Am J Transl Res
2016[]; 8
(3
): 1593-600
PMID27186284
show ga
BACKGROUND: Tacrolimus inhibits hepatitis B virus entry into hepatocytes through
targeting the HBV receptor, sodium taurocholate cotransporting polypeptide. This
study was performed to evaluate the efficacy and safety of Tacrolimus combined
with entecavir antiviral therapy for HBV-associated glomerulonephritis patients
with biopsy-proven membranous nephropathy. METHOD: A cohort of 42 patients was
enrolled in this retrospective study. Twenty-three patients received Tacrolimus
(0.05 mg/kg/day) in combination entecavir over 24 weeks, whereas the other 19
patients only received entecavir monotherapy. RESULTS: The probability of
proteinuria remission in the Tacrolimus+entecavir group was 69 and 87% after 12
and 24 weeks, whereas was only 26 and 42%, respectively, in the entecavir group.
The mean time to partial or complete remission was 18.6 weeks in the
Tacrolimus+entecavir group and 34.3 weeks in the entecavir group (P<0.001). A
decrease in the HBV DNA titer was observed in all patients with active HBV
replication. None of the HBV carriers in the Tacrolimus+entecavir group showed
evidence of HBV reactivation. The serum creatinine and alanine aminotransferase
levels remained stable in both groups. The Tacrolimus target trough concentration
was 5-10 ng/mL. CONCLUSION: Tacrolimus combined with entecavir rapidly and
effectively induced remission of HBV-GN in Chinese adults. Furthermore,
Tacrolimus may have a synergistic antiviral effect with entecavir.