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10.1371/journal.pbio.1002459 http://scihub22266oqcxt.onion/10.1371/journal.pbio.1002459 C4859536!4859536!27152726     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Biol 2016 ; 14 (5): ä Nephropedia Template TP {{tp|p=27152726|t=2016. Platelets Guide Leukocytes to Their Sites of Extravasation |pdf=|usr=}}{{27152726}} gab.com Text Platelets Guide Leukocytes to Their Sites of Extravasation JO: PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=27152726 #FOAvip Effective immune responses require the directed migration of leukocytes from the vasculature to the site of injury or infection. How immune cells ?find? their site of extravasation remains largely obscure. Here, we identified a previously unrecognized role of platelets as pathfinders guiding leukocytes to their exit points in the microvasculature: upon onset of inflammation, circulating platelets were found to immediately adhere at distinct sites in venular microvessels enabling these cellular blood components to capture neutrophils and, in turn, inflammatory monocytes via CD40-CD40L-dependent interactions. In this cellular crosstalk, ligation of PSGL-1 by P-selectin leads to ERK1/2 MAPK-dependent conformational changes of leukocyte integrins, which promote the successive extravasation of neutrophils and monocytes to the perivascular tissue. Conversely, blockade of this cellular partnership resulted in misguided, inefficient leukocyte responses. Our experimental data uncover a platelet-directed, spatiotemporally organized, multicellular crosstalk that is essential for effective trafficking of leukocytes to the site of inflammation. Twit Text FOAVip Platelets Guide Leukocytes to Their Sites of Extravasation ????PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=27152726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27152726 #FOAvip English Wikipedia <ref>{{Cite pmid|27152726}}</ref> Platelets Guide Leukocytes to Their Sites of Extravasation #MMPMID27152726 Zuchtriegel G; Uhl B; Puhr-Westerheide D; Pörnbacher M; Lauber K; Krombach F; Reichel CA PLoS Biol 2016[May]; 14 (5): ä PMID27152726show ga Effective immune responses require the directed migration of leukocytes from the vasculature to the site of injury or infection. How immune cells ?find? their site of extravasation remains largely obscure. Here, we identified a previously unrecognized role of platelets as pathfinders guiding leukocytes to their exit points in the microvasculature: upon onset of inflammation, circulating platelets were found to immediately adhere at distinct sites in venular microvessels enabling these cellular blood components to capture neutrophils and, in turn, inflammatory monocytes via CD40-CD40L-dependent interactions. In this cellular crosstalk, ligation of PSGL-1 by P-selectin leads to ERK1/2 MAPK-dependent conformational changes of leukocyte integrins, which promote the successive extravasation of neutrophils and monocytes to the perivascular tissue. Conversely, blockade of this cellular partnership resulted in misguided, inefficient leukocyte responses. Our experimental data uncover a platelet-directed, spatiotemporally organized, multicellular crosstalk that is essential for effective trafficking of leukocytes to the site of inflammation. äPlatelets Guide Leukocytes to Their Sites of Extravasation (epmc).pdf DeepDyve Pubget Overpricing