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2016 ; 8
(Suppl 2
): 15-33
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The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics,
and Immunology Advancements
#MMPMID27168728
Gaudreau PO
; Stagg J
; Soulières D
; Saad F
Biomark Cancer
2016[]; 8
(Suppl 2
): 15-33
PMID27168728
show ga
Prostate cancer (PC) is the second most common form of cancer in men worldwide.
Biomarkers have emerged as essential tools for treatment and assessment since the
variability of disease behavior, the cost and diversity of treatments, and the
related impairment of quality of life have given rise to a need for a
personalized approach. High-throughput technology platforms in proteomics and
genomics have accelerated the development of biomarkers. Furthermore, recent
successes of several new agents in PC, including immunotherapy, have stimulated
the search for predictors of response and resistance and have improved the
understanding of the biological mechanisms at work. This review provides an
overview of currently established biomarkers in PC, as well as a selection of the
most promising biomarkers within these particular fields of development.