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10.1161/JAHA.115.002856 http://scihub22266oqcxt.onion/10.1161/JAHA.115.002856 C4859399!4859399 !26811168     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26811168 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair |pdf=|usr=}}{{26811168 }} gab.com Text Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=26811168 #FOAvip BACKGROUND: Exosomes derived from mesenchymal stem cells (MSCs) were proved to boost cell proliferation and angiogenic potency. We explored whether cardiac stem cells (CSCs) preconditioned with MSC exosomes could survive and function better in a myocardial infarction model. METHODS AND RESULTS: DiI-labeled exosomes were internalized with CSCs. They stimulated proliferation, migration, and angiotube formation of CSCs in a dose-dependent manner. In a rat myocardial infarction model, MSC exosome-preconditioned CSCs had significantly better survival, enhanced capillary density, reduced cardiac fibrosis, and restored long-term cardiac function. MicroRNA profiling analysis revealed that a set of microRNAs were significantly changed in CSCs after MSC exosome treatment. CONCLUSIONS: Pretreatment of CSCs with MSC exosomes provided a promising strategy to improve survival and angiogenic potency of CSCs. Twit Text FOAVip Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=26811168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26811168 #FOAvip English Wikipedia <ref>{{Cite pmid|26811168 }}</ref> Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair #MMPMID26811168 Zhang Z ; Yang J ; Yan W ; Li Y ; Shen Z ; Asahara T J Am Heart Assoc 2016[Jan]; 5 (1 ): ä PMID26811168 show ga BACKGROUND: Exosomes derived from mesenchymal stem cells (MSCs) were proved to boost cell proliferation and angiogenic potency. We explored whether cardiac stem cells (CSCs) preconditioned with MSC exosomes could survive and function better in a myocardial infarction model. METHODS AND RESULTS: DiI-labeled exosomes were internalized with CSCs. They stimulated proliferation, migration, and angiotube formation of CSCs in a dose-dependent manner. In a rat myocardial infarction model, MSC exosome-preconditioned CSCs had significantly better survival, enhanced capillary density, reduced cardiac fibrosis, and restored long-term cardiac function. MicroRNA profiling analysis revealed that a set of microRNAs were significantly changed in CSCs after MSC exosome treatment. CONCLUSIONS: Pretreatment of CSCs with MSC exosomes provided a promising strategy to improve survival and angiogenic potency of CSCs. |*Neovascularization, Physiologic [MESH] |*Regeneration [MESH] |Animals [MESH] |Animals, Newborn [MESH] |Cell Differentiation [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Endothelial Progenitor Cells/metabolism/*transplantation [MESH] |Exosomes/*metabolism [MESH] |Fibrosis [MESH] |Gene Expression Regulation [MESH] |Gene Regulatory Networks [MESH] |Mesenchymal Stem Cells/*metabolism [MESH] |MicroRNAs/genetics/metabolism [MESH] |Myocardial Infarction/genetics/metabolism/pathology/physiopathology/*surgery [MESH] |Myocardium/*metabolism/pathology [MESH] |Myocytes, Cardiac/metabolism/pathology/*transplantation [MESH] |Phenotype [MESH] |Rats, Sprague-Dawley [MESH] |Recovery of Function [MESH] |Signal Transduction [MESH] |Stem Cell Transplantation/*methods [MESH] |Stroke Volume [MESH] |Time Factors [MESH]Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchy(epmc).pdf DeepDyve Pubget Overpricing