Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27183565
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate
Specification, and Plasticity
#MMPMID27183565
Sundaram MV
; Buechner M
Genetics
2016[May]; 203
(1
): 35-63
PMID27183565
show ga
The excretory system of the nematode Caenorhabditis elegans is a superb model of
tubular organogenesis involving a minimum of cells. The system consists of just
three unicellular tubes (canal, duct, and pore), a secretory gland, and two
associated neurons. Just as in more complex organs, cells of the excretory system
must first adopt specific identities and then coordinate diverse processes to
form tubes of appropriate topology, shape, connectivity, and physiological
function. The unicellular topology of excretory tubes, their varied and sometimes
complex shapes, and the dynamic reprogramming of cell identity and remodeling of
tube connectivity that occur during larval development are particularly
fascinating features of this organ. The physiological roles of the excretory
system in osmoregulation and other aspects of the animal's life cycle are only
beginning to be explored. The cellular mechanisms and molecular pathways used to
build and shape excretory tubes appear similar to those used in both unicellular
and multicellular tubes in more complex organs, such as the vertebrate vascular
system and kidney, making this simple organ system a useful model for
understanding disease processes.
free
free
free
