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10.1371/journal.ppat.1005572 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1005572 C4858270!4858270 !27149619     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27149619 &cmd=llinks): Failed to open stream: HTTP request failed! 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Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons |pdf=|usr=}}{{27149619 }} gab.com Text Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=27149619 #FOAvip Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as vomiting and diarrhea. However, the molecular mechanisms remain incompletely defined. Using an influenza mouse model, we found that influenza pulmonary infection can significantly alter the intestinal microbiota profile through a mechanism dependent on type I interferons (IFN-Is). Notably, influenza-induced IFN-Is produced in the lungs promote the depletion of obligate anaerobic bacteria and the enrichment of Proteobacteria in the gut, leading to a "dysbiotic" microenvironment. Additionally, we provide evidence that IFN-Is induced in the lungs during influenza pulmonary infection inhibit the antimicrobial and inflammatory responses in the gut during Salmonella-induced colitis, further enhancing Salmonella intestinal colonization and systemic dissemination. Thus, our studies demonstrate a systemic role for IFN-Is in regulating the host immune response in the gut during Salmonella-induced colitis and in altering the intestinal microbial balance after influenza infection. Twit Text FOAVip Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=27149619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27149619 #FOAvip English Wikipedia <ref>{{Cite pmid|27149619 }}</ref> Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons #MMPMID27149619 Deriu E ; Boxx GM ; He X ; Pan C ; Benavidez SD ; Cen L ; Rozengurt N ; Shi W ; Cheng G PLoS Pathog 2016[May]; 12 (5 ): e1005572 PMID27149619 show ga Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as vomiting and diarrhea. However, the molecular mechanisms remain incompletely defined. Using an influenza mouse model, we found that influenza pulmonary infection can significantly alter the intestinal microbiota profile through a mechanism dependent on type I interferons (IFN-Is). Notably, influenza-induced IFN-Is produced in the lungs promote the depletion of obligate anaerobic bacteria and the enrichment of Proteobacteria in the gut, leading to a "dysbiotic" microenvironment. Additionally, we provide evidence that IFN-Is induced in the lungs during influenza pulmonary infection inhibit the antimicrobial and inflammatory responses in the gut during Salmonella-induced colitis, further enhancing Salmonella intestinal colonization and systemic dissemination. Thus, our studies demonstrate a systemic role for IFN-Is in regulating the host immune response in the gut during Salmonella-induced colitis and in altering the intestinal microbial balance after influenza infection. |Animals [MESH] |Coinfection/immunology/microbiology [MESH] |Disease Models, Animal [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Gastrointestinal Microbiome/*immunology [MESH] |Immunoblotting [MESH] |Interferon Type I/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Orthomyxoviridae Infections/complications/*immunology [MESH] |Real-Time Polymerase Chain Reaction [MESH]Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella(epmc).pdf DeepDyve Pubget Overpricing