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10.1371/journal.pone.0155040 http://scihub22266oqcxt.onion/10.1371/journal.pone.0155040 C4858255!4858255!27148746     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (5): ä Nephropedia Template TP {{tp|p=27148746|t=2016. Stat3 Is Important for Follicular Regulatory T Cell Differentiation |pdf=|usr=}}{{27148746}} gab.com Text Stat3 Is Important for Follicular Regulatory T Cell Differentiation JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27148746 #FOAvip The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood. Here, we found that Stat3 is indispensible for Tfr cell differentiation. After immunization with Sheep Red Blood Cells (SRBC), the loss of Tfr cells caused by deletion of Stat3 in Treg cells does not affect the size of Tfh or GC B cell population, but rather leads to strongly enhanced production of antigen-specific IgG1 and IgG2b. In Peyer?s patches (PPs) in the gut, we found that Stat3 expression in Treg cells is also required for Tfr cell formation to commensal organisms. However, loss of Tfr cells in the gut did not affect the numbers of Tfh cells and GC B cells, nor affect IgG1 or IgA switching by GC B cells. Overall, our study has uncovered unique roles of Stat3 in Tfr cell differentiation and the regulation of the antibody response. Twit Text FOAVip Stat3 Is Important for Follicular Regulatory T Cell Differentiation ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27148746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27148746 #FOAvip English Wikipedia <ref>{{Cite pmid|27148746}}</ref> Stat3 Is Important for Follicular Regulatory T Cell Differentiation #MMPMID27148746 Wu H; Xie MM; Liu H; Dent AL PLoS One 2016[]; 11 (5): ä PMID27148746show ga The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood. Here, we found that Stat3 is indispensible for Tfr cell differentiation. After immunization with Sheep Red Blood Cells (SRBC), the loss of Tfr cells caused by deletion of Stat3 in Treg cells does not affect the size of Tfh or GC B cell population, but rather leads to strongly enhanced production of antigen-specific IgG1 and IgG2b. In Peyer?s patches (PPs) in the gut, we found that Stat3 expression in Treg cells is also required for Tfr cell formation to commensal organisms. However, loss of Tfr cells in the gut did not affect the numbers of Tfh cells and GC B cells, nor affect IgG1 or IgA switching by GC B cells. Overall, our study has uncovered unique roles of Stat3 in Tfr cell differentiation and the regulation of the antibody response. äStat3 Is Important for Follicular Regulatory T Cell Differentiation (epmc).pdf DeepDyve Pubget Overpricing