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10.1111/jvim.13590 http://scihub22266oqcxt.onion/10.1111/jvim.13590 C4858039!4858039!26256847     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26256847.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Vet+Intern+Med 2015 ; 29 (5): 1395-402 Nephropedia Template TP {{tp|p=26256847|t=2015. Physicochemical Approach to Determine the Mechanism for Acid?Base Disorders in 793 Hospitalized Foals |pdf=|usr=}}{{26256847}} gab.com Text Physicochemical Approach to Determine the Mechanism for Acid Base Disorders in 793 Hospitalized Foals JO: J Vet Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=26256847 #FOAvip Background: The quantitative effect of strong electrolytes, unmeasured strong anions (UAs), pCO2, and plasma protein concentrations in determining plasma pH can be demonstrated using the physicochemical approach. Plasma anion gap (AG) and strong ion gap (SIG) are used to assess UAs in different species. Hypotheses: Strong ions are a major factor influencing changes in plasma pH of hospitalized foals. AG and SIG accurately predict severe hyper?l?lactatemia ([l?lac?] > 7 mmol/L). Animals: Seven hundred and ninety three hospitalized foals < 7 days old. Methods: Retrospective study. The relationship between measured pH and physicochemical variables, and the relationship between plasma [l?lac?] and AG and SIG, were determined using regression analyses. Optimal AG and SIG cut points to predict hyper?l?lactatemia were identified using an ROC curve analysis. Results: Combined, the measured strong ion difference and SIG accounted for 54?69% of the changes in the measured arterial pH of hospitalized foals. AG and SIG were significantly associated with plasma [l?lac?] (P < .0001). The receiver operator characteristics (ROC) AUC of AG and SIG for prediction of severe hyper?l?lactatemia were 0.89 (95%CI, 0.8?0.95; P < .0001) and 0.90 (95%CI, 0.81?0.96; P < .0001), respectively. Severe hyper?l?lactatemia was best predicted by AG > 27 mmol/L (sensitivity 80%, 95%CI, 56?94, specificity 85%, 95%CI, 73?93; P < .0001) and SIG <?15 mmol/L (sensitivity 90%, 95%CI, 68?98; specificity 80%; 95%CI, 68?90; P < .0001). Conclusion and clinical relevance: Altered concentrations of strong ions (Na+, K+, Cl?) and UAs were the primary cause of acidemia of hospitalized foals. AG and SIG were good predictors of hyper?l?lactatemia and could be used as surrogate tests. Twit Text FOAVip Physicochemical Approach to Determine the Mechanism for Acid Base Disorders in 793 Hospitalized Foals ????J Vet Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=26256847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26256847 #FOAvip English Wikipedia <ref>{{Cite pmid|26256847}}</ref> Physicochemical Approach to Determine the Mechanism for Acid?Base Disorders in 793 Hospitalized Foals #MMPMID26256847 Gomez D; Biermann N; Sanchez L J Vet Intern Med 2015[Sep]; 29 (5): 1395-402 PMID26256847show ga Background: The quantitative effect of strong electrolytes, unmeasured strong anions (UAs), pCO2, and plasma protein concentrations in determining plasma pH can be demonstrated using the physicochemical approach. Plasma anion gap (AG) and strong ion gap (SIG) are used to assess UAs in different species. Hypotheses: Strong ions are a major factor influencing changes in plasma pH of hospitalized foals. AG and SIG accurately predict severe hyper?l?lactatemia ([l?lac?] > 7 mmol/L). Animals: Seven hundred and ninety three hospitalized foals < 7 days old. Methods: Retrospective study. The relationship between measured pH and physicochemical variables, and the relationship between plasma [l?lac?] and AG and SIG, were determined using regression analyses. Optimal AG and SIG cut points to predict hyper?l?lactatemia were identified using an ROC curve analysis. Results: Combined, the measured strong ion difference and SIG accounted for 54?69% of the changes in the measured arterial pH of hospitalized foals. AG and SIG were significantly associated with plasma [l?lac?] (P < .0001). The receiver operator characteristics (ROC) AUC of AG and SIG for prediction of severe hyper?l?lactatemia were 0.89 (95%CI, 0.8?0.95; P < .0001) and 0.90 (95%CI, 0.81?0.96; P < .0001), respectively. Severe hyper?l?lactatemia was best predicted by AG > 27 mmol/L (sensitivity 80%, 95%CI, 56?94, specificity 85%, 95%CI, 73?93; P < .0001) and SIG äPhysicochemical Approach to Determine the Mechanism for Acid?Base Diso(epmc).pdf DeepDyve Pubget Overpricing