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10.1159/000433473 http://scihub22266oqcxt.onion/10.1159/000433473 C4857825!4857825!27170937     free     free     free       Skin+Appendage+Disord 2015 ; 1 (2): 74-81 Nephropedia Template TP {{tp|p=27170937|t=2015. Network Meta-Analysis of Onychomycosis Treatments |pdf=|usr=}}{{27170937}} gab.com Text Network Meta-Analysis of Onychomycosis Treatments JO: Skin Appendage Disord http://www.kidney.de/pget.php?&tw=1&pmid=27170937 #FOAvip Background: Many onychomycosis treatments have not been directly compared in head-to-head clinical trials. Objective: To determine the relative efficacy of onychomycosis treatments using network meta-analysis (NMA). Methods: We conducted a systematic review and NMA of mycological cure rates. Results: Nineteen trials were included in the network. Terbinafine 250 mg was significantly superior to all treatments except itraconazole 400 mg pulse therapy. The itraconazole 400 mg pulse regimen was significantly superior to all topicals except efinaconazole 10% nail solution. Itraconazole 200 mg was significantly superior to all topical treatments, while fluconazole 150-450 mg, efinaconazole 10% nail solution, tavaborole 5% nail solution, ciclopirox nail lacquer 8%, terbinafine nail solution, and amorolfine 5% nail lacquer were significantly superior to placebo. Conclusions: Newly developed topicals have improved the odds ratios (ORs) of mycological cure, yet these ORs were not significantly greater than preexisting topical treatments. Further experience with these agents will reveal their clinical significance, and head-to-head trials are warranted.© 2015 S. Karger AG, Basel Twit Text FOAVip Network Meta-Analysis of Onychomycosis Treatments ????Skin Appendage Disord http://www.kidney.de/pget.php?&tw=1&pmid=27170937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27170937 #FOAvip English Wikipedia <ref>{{Cite pmid|27170937}}</ref> Network Meta-Analysis of Onychomycosis Treatments #MMPMID27170937 Gupta AK; Daigle D; Foley KA Skin Appendage Disord 2015[Sep]; 1 (2): 74-81 PMID27170937show ga Background: Many onychomycosis treatments have not been directly compared in head-to-head clinical trials. Objective: To determine the relative efficacy of onychomycosis treatments using network meta-analysis (NMA). Methods: We conducted a systematic review and NMA of mycological cure rates. Results: Nineteen trials were included in the network. Terbinafine 250 mg was significantly superior to all treatments except itraconazole 400 mg pulse therapy. The itraconazole 400 mg pulse regimen was significantly superior to all topicals except efinaconazole 10% nail solution. Itraconazole 200 mg was significantly superior to all topical treatments, while fluconazole 150-450 mg, efinaconazole 10% nail solution, tavaborole 5% nail solution, ciclopirox nail lacquer 8%, terbinafine nail solution, and amorolfine 5% nail lacquer were significantly superior to placebo. Conclusions: Newly developed topicals have improved the odds ratios (ORs) of mycological cure, yet these ORs were not significantly greater than preexisting topical treatments. Further experience with these agents will reveal their clinical significance, and head-to-head trials are warranted.© 2015 S. Karger AG, Basel äNetwork Meta-Analysis of Onychomycosis Treatments (epmc).pdf DeepDyve Pubget Overpricing