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10.1093/nar/gkw135 http://scihub22266oqcxt.onion/10.1093/nar/gkw135 C4856988!4856988 !27060145     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27060145 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2016 ; 44 (8 ): 3503-12 Nephropedia Template TP {{tp|p=27060145 |t=2016. Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains |pdf=|usr=}}{{27060145 }} gab.com Text Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27060145 #FOAvip Biophysicists are modeling conformations of interphase chromosomes, often basing the strengths of interactions between segments distant on the genetic map on contact frequencies determined experimentally. Here, instead, we develop a fitting-free, minimal model: bivalent or multivalent red and green 'transcription factors' bind to cognate sites in strings of beads ('chromatin') to form molecular bridges stabilizing loops. In the absence of additional explicit forces, molecular dynamic simulations reveal that bound factors spontaneously cluster-red with red, green with green, but rarely red with green-to give structures reminiscent of transcription factories. Binding of just two transcription factors (or proteins) to active and inactive regions of human chromosomes yields rosettes, topological domains and contact maps much like those seen experimentally. This emergent 'bridging-induced attraction' proves to be a robust, simple and generic force able to organize interphase chromosomes at all scales. Twit Text FOAVip Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27060145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27060145 #FOAvip English Wikipedia <ref>{{Cite pmid|27060145 }}</ref> Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains #MMPMID27060145 Brackley CA ; Johnson J ; Kelly S ; Cook PR ; Marenduzzo D Nucleic Acids Res 2016[May]; 44 (8 ): 3503-12 PMID27060145 show ga Biophysicists are modeling conformations of interphase chromosomes, often basing the strengths of interactions between segments distant on the genetic map on contact frequencies determined experimentally. Here, instead, we develop a fitting-free, minimal model: bivalent or multivalent red and green 'transcription factors' bind to cognate sites in strings of beads ('chromatin') to form molecular bridges stabilizing loops. In the absence of additional explicit forces, molecular dynamic simulations reveal that bound factors spontaneously cluster-red with red, green with green, but rarely red with green-to give structures reminiscent of transcription factories. Binding of just two transcription factors (or proteins) to active and inactive regions of human chromosomes yields rosettes, topological domains and contact maps much like those seen experimentally. This emergent 'bridging-induced attraction' proves to be a robust, simple and generic force able to organize interphase chromosomes at all scales. |*Molecular Dynamics Simulation [MESH] |Chromatin/metabolism [MESH] |Chromosome Mapping/*methods [MESH] |Chromosomes, Human/*chemistry/*ultrastructure [MESH] |Computational Biology/*methods [MESH] |Genome, Human/genetics [MESH] |Humans [MESH] |Protein Binding/genetics [MESH]Simulated binding of transcription factors to active and inactive regi(epmc).pdf DeepDyve Pubget Overpricing