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10.1016/j.apsb.2016.02.004 http://scihub22266oqcxt.onion/10.1016/j.apsb.2016.02.004 C4856949!4856949!27175328     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharm+Sin+B 2016 ; 6 (3): 183-8 Nephropedia Template TP {{tp|p=27175328|t=2016. The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases |pdf=|usr=}}{{27175328}} gab.com Text The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases JO: Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=27175328 #FOAvip High mobility group box 1 (HMGB1) is a nuclear protein that can bind to DNA and act as a co-factor for gene transcription. When released into extracellular fluid, it plays a proinflammatory role by acting as a damage-associated molecular pattern molecule (DAMP) (also known as an alarmin) to initiate innate immune responses by activating multiple cell surface receptors such as the receptor for advanced glycation end-products (RAGE) and toll-like receptors (TLRs), TLR2, TLR4 or TLR9. This proinflammatory role is now considered to be important in the pathogenesis of a wide range of kidney diseases whether they result from hemodynamic changes, renal tubular epithelial cell apoptosis, kidney tissue fibrosis or inflammation. This review summarizes our current understanding of the role of HMGB1 in kidney diseases and how the HMGB1-mediated signaling pathway may constitute a new strategy for the treatment of kidney diseases. Twit Text FOAVip The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases ????Acta Pharm Sin B http://www.kidney.de/pget.php?&tw=1&pmid=27175328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27175328 #FOAvip English Wikipedia <ref>{{Cite pmid|27175328}}</ref> The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases #MMPMID27175328 Chen Q; Guan X; Zuo X; Wang J; Yin W Acta Pharm Sin B 2016[May]; 6 (3): 183-8 PMID27175328show ga High mobility group box 1 (HMGB1) is a nuclear protein that can bind to DNA and act as a co-factor for gene transcription. When released into extracellular fluid, it plays a proinflammatory role by acting as a damage-associated molecular pattern molecule (DAMP) (also known as an alarmin) to initiate innate immune responses by activating multiple cell surface receptors such as the receptor for advanced glycation end-products (RAGE) and toll-like receptors (TLRs), TLR2, TLR4 or TLR9. This proinflammatory role is now considered to be important in the pathogenesis of a wide range of kidney diseases whether they result from hemodynamic changes, renal tubular epithelial cell apoptosis, kidney tissue fibrosis or inflammation. This review summarizes our current understanding of the role of HMGB1 in kidney diseases and how the HMGB1-mediated signaling pathway may constitute a new strategy for the treatment of kidney diseases. äThe role of high mobility group box 1 (HMGB1) in the pathogenesis of k(epmc).pdf DeepDyve Pubget Overpricing