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10.1155/2016/5279462 http://scihub22266oqcxt.onion/10.1155/2016/5279462 C4856917!4856917!27200090     free     free     free       Int+J+Endocrinol 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=27200090|t=2016. 11?-Hydroxysteroid Dehydrogenase 2 in Preeclampsia |pdf=|usr=}}{{27200090}} gab.com Text 11 -Hydroxysteroid Dehydrogenase 2 in Preeclampsia JO: Int J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=27200090 #FOAvip Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology of preeclampsia is the deficiency in placental 11?-hydroxysteroid dehydrogenase 2 (11?-HSD2), the enzyme which in normal pregnancy protects the fetus from the excess of maternal cortisol. The reduced activity of the enzyme was observed in placentas from pregnancies complicated with preeclampsia. That suggests the overexposure of the developing child to maternal cortisol, which in high levels exerts proapoptotic effects and reduces fetal growth. The fetal growth restriction due to the diminished placental 11?-HSD2 function may be supported by the fact that preeclampsia is often accompanied with fetal hypotrophy. The causes of the reduced function of 11?-HSD2 in placental tissue are still discussed. This paper summarizes the phenomena that may affect the activity of the enzyme at various steps on the way from the gene to the protein. Twit Text FOAVip 11 -Hydroxysteroid Dehydrogenase 2 in Preeclampsia ????Int J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=27200090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27200090 #FOAvip English Wikipedia <ref>{{Cite pmid|27200090}}</ref> 11?-Hydroxysteroid Dehydrogenase 2 in Preeclampsia #MMPMID27200090 Kosicka K; Siemi?tkowska A; G?ówka FK Int J Endocrinol 2016[]; 2016 (ä): ä PMID27200090show ga Preeclampsia is a serious medical problem affecting the mother and her child and influences their health not only during the pregnancy, but also many years after. Although preeclampsia is a subject of many research projects, the etiology of the condition remains unclear. One of the hypotheses related to the etiology of preeclampsia is the deficiency in placental 11?-hydroxysteroid dehydrogenase 2 (11?-HSD2), the enzyme which in normal pregnancy protects the fetus from the excess of maternal cortisol. The reduced activity of the enzyme was observed in placentas from pregnancies complicated with preeclampsia. That suggests the overexposure of the developing child to maternal cortisol, which in high levels exerts proapoptotic effects and reduces fetal growth. The fetal growth restriction due to the diminished placental 11?-HSD2 function may be supported by the fact that preeclampsia is often accompanied with fetal hypotrophy. The causes of the reduced function of 11?-HSD2 in placental tissue are still discussed. This paper summarizes the phenomena that may affect the activity of the enzyme at various steps on the way from the gene to the protein. ä11?-Hydroxysteroid Dehydrogenase 2 in Preeclampsia (epmc).pdf DeepDyve Pubget Overpricing