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2016 ; 2016
(ä): 9106935
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English Wikipedia
Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a
Hemodialysis Patient
#MMPMID27200198
Frassetto LA
; Gibson S
Case Rep Nephrol
2016[]; 2016
(ä): 9106935
PMID27200198
show ga
Uric acid accumulates in renal failure and is thought to be a uremic toxin-that
is, higher levels of uric acid are more damaging to the kidneys. Urate crystals
can precipitate in the kidney tubules, cause urate stones, and promote
inflammatory changes in the renal interstitium and vascular endothelium. Uric
acid is also a small non-protein-bound molecule and therefore easily dialyzable.
Here, we present the case of an anuric hemodialysis patient with severe
tophaceous gout who regained some renal function and whose gout burden
significantly decreased resulting in marked improvement in functional status
using a new gout medication, febuxostat, and increased frequency of dialysis.