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Lycium barbarum Polysaccharide Mediated the Antidiabetic and Antinephritic
Effects in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats via
Regulation of NF-?B
#MMPMID27200371
Du M
; Hu X
; Kou L
; Zhang B
; Zhang C
Biomed Res Int
2016[]; 2016
(?): 3140290
PMID27200371
show ga
Lycium barbarum, extensively utilized as a medicinal plant in China for years,
exhibits antitumor, immunoregulative, hepatoprotective, and neuroprotective
properties. The present study aims to investigate the hyperglycemic and
antidiabetic nephritic effects of polysaccharide which is separated from Lycium
barbarum (LBPS) in high-fat diet-streptozotocin- (STZ-) induced rat models. The
reduced bodyweight and enhanced blood glucose concentration in serum were
observed in diabetic rats, and they were significantly normalized to the healthy
level by 100?mg/kg of metformin (Met) and LBPS at doses of 100, 250, and
500?mg/kg. LBPS inhibited albuminuria and blood urea nitrogen concentration and
serum levels of inflammatory factors including IL-2, IL-6, TNF-?, IFN-?, MCP-1,
and ICAM-1 compared with diabetic rats, and it indicates the protection on renal
damage. Furthermore, the activities of SOD and GSH-Px in serum were enhanced
strikingly by LBPS which suggests its antioxidation effects. LBPS, compared with
nontreated diabetic rats, inhibited the expression of phosphor-nuclear factors
kappa B (NF-?B) and inhibitor kappa B alpha in kidney tissues. Collectively, LBPS
possesses antidiabetic and antinephritic effects related to NF-?B-mediated
antioxidant and antiinflammatory activities.
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