Circulating Permeability Factors in Primary Focal Segmental Glomerulosclerosis: A
Review of Proposed Candidates
#MMPMID27200372
Königshausen E
; Sellin L
Biomed Res Int
2016[]; 2016
(?): 3765608
PMID27200372
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Primary focal segmental glomerulosclerosis (FSGS) is a major cause of the
nephrotic syndrome and often leads to end-stage renal disease. This review
focuses on circulating permeability factors in primary FSGS that have been
implicated in the pathogenesis for a long time, partly due to the potential
recurrence in renal allografts within hours after transplantation. Recently,
three molecules have been proposed as a potential permeability factor by
different groups: the soluble urokinase plasminogen activator receptor (suPAR),
cardiotrophin-like cytokine factor-1 (CLCF-1), and CD40 antibodies. Both CLCF-1
and CD40 antibodies have not been validated by independent research groups yet.
Since the identification of suPAR, different studies have questioned the validity
of suPAR as a biomarker to distinguish primary FSGS from other proteinuric kidney
diseases as well as suPAR's pathogenic role in podocyte damage. Researchers have
suggested that cleaved molecules of suPAR have a pathogenic role in FSGS but
further studies are needed to determine this role. In future studies, proposed
standards for the research of the permeability factor should be carefully
followed. The identification of the permeability factor in primary FSGS would be
of great clinical relevance as it could influence potential individual treatment
regimen.
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