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10.1038/cmi.2016.5 http://scihub22266oqcxt.onion/10.1038/cmi.2016.5 C4856811!4856811!27041636     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2016 ; 13 (3): 347-53 Nephropedia Template TP {{tp|p=27041636|t=2016. Immunological functions of liver sinusoidal endothelial cells |pdf=|usr=}}{{27041636}} gab.com Text Immunological functions of liver sinusoidal endothelial cells JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27041636 #FOAvip Liver sinusoidal endothelial cells (LSECs) line the liver sinusoids and separate passenger leukocytes in the sinusoidal lumen from hepatocytes. LSECs further act as a platform for adhesion of various liver-resident immune cell populations such as Kupffer cells, innate lymphoid cells or liver dendritic cells. In addition to having an extraordinary scavenger function, LSECs possess potent immune functions, serving as sentinel cells to detect microbial infection through pattern recognition receptor activation and as antigen (cross)-presenting cells. LSECs cross-prime naive CD8 T cells, causing their rapid differentiation into memory T cells that relocate to secondary lymphoid tissues and provide protection when they re-encounter the antigen during microbial infection. Cross-presentation of viral antigens by LSECs derived from infected hepatocytes triggers local activation of effector CD8 T cells and thereby assures hepatic immune surveillance. The immune function of LSECs complements conventional immune-activating mechanisms to accommodate optimal immune surveillance against infectious microorganisms while preserving the integrity of the liver as a metabolic organ. Twit Text FOAVip Immunological functions of liver sinusoidal endothelial cells ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27041636 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27041636 #FOAvip English Wikipedia <ref>{{Cite pmid|27041636}}</ref> Immunological functions of liver sinusoidal endothelial cells #MMPMID27041636 Knolle PA; Wohlleber D Cell Mol Immunol 2016[May]; 13 (3): 347-53 PMID27041636show ga Liver sinusoidal endothelial cells (LSECs) line the liver sinusoids and separate passenger leukocytes in the sinusoidal lumen from hepatocytes. LSECs further act as a platform for adhesion of various liver-resident immune cell populations such as Kupffer cells, innate lymphoid cells or liver dendritic cells. In addition to having an extraordinary scavenger function, LSECs possess potent immune functions, serving as sentinel cells to detect microbial infection through pattern recognition receptor activation and as antigen (cross)-presenting cells. LSECs cross-prime naive CD8 T cells, causing their rapid differentiation into memory T cells that relocate to secondary lymphoid tissues and provide protection when they re-encounter the antigen during microbial infection. Cross-presentation of viral antigens by LSECs derived from infected hepatocytes triggers local activation of effector CD8 T cells and thereby assures hepatic immune surveillance. The immune function of LSECs complements conventional immune-activating mechanisms to accommodate optimal immune surveillance against infectious microorganisms while preserving the integrity of the liver as a metabolic organ. äImmunological functions of liver sinusoidal endothelial cells (epmc).pdf DeepDyve Pubget Overpricing