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10.1038/cmi.2015.115 http://scihub22266oqcxt.onion/10.1038/cmi.2015.115 C4856801!4856801!26972772     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Immunol 2016 ; 13 (3): 337-46 Nephropedia Template TP {{tp|p=26972772|t=2016. NKT cell subsets as key participants in liver physiology and pathology |pdf=|usr=}}{{26972772}} gab.com Text NKT cell subsets as key participants in liver physiology and pathology JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26972772 #FOAvip Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated by self- or microbial-lipid antigens and by signaling through toll-like receptors. Following activation, NKT cells rapidly secrete pro-inflammatory or anti-inflammatory cytokines and chemokines, and thereby determine the milieu for subsequent immunity or tolerance. It is becoming clear that two different subsets of NKT cells?type I and type II?have different modes of antigen recognition and have opposing roles in inflammatory liver diseases. Here we focus mainly on the roles of both NKT cell subsets in the maintenance of immune tolerance and inflammatory diseases in liver. Furthermore, how the differential activation of type I and type II NKT cells influences other innate cells and adaptive immune cells to result in important consequences for tissue integrity is discussed. It is crucial that better reagents, including CD1d tetramers, be used in clinical studies to define the roles of NKT cells in liver diseases in patients. Twit Text FOAVip NKT cell subsets as key participants in liver physiology and pathology ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26972772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26972772 #FOAvip English Wikipedia <ref>{{Cite pmid|26972772}}</ref> NKT cell subsets as key participants in liver physiology and pathology #MMPMID26972772 Bandyopadhyay K; Marrero I; Kumar V Cell Mol Immunol 2016[May]; 13 (3): 337-46 PMID26972772show ga Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated by self- or microbial-lipid antigens and by signaling through toll-like receptors. Following activation, NKT cells rapidly secrete pro-inflammatory or anti-inflammatory cytokines and chemokines, and thereby determine the milieu for subsequent immunity or tolerance. It is becoming clear that two different subsets of NKT cells?type I and type II?have different modes of antigen recognition and have opposing roles in inflammatory liver diseases. Here we focus mainly on the roles of both NKT cell subsets in the maintenance of immune tolerance and inflammatory diseases in liver. Furthermore, how the differential activation of type I and type II NKT cells influences other innate cells and adaptive immune cells to result in important consequences for tissue integrity is discussed. It is crucial that better reagents, including CD1d tetramers, be used in clinical studies to define the roles of NKT cells in liver diseases in patients. äNKT cell subsets as key participants in liver physiology and pathology(epmc).pdf DeepDyve Pubget Overpricing