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10.1038/jhh.2015.103

http://scihub22266oqcxt.onion/10.1038/jhh.2015.103
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C4856755!4856755!26446393
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pmid26446393      J+Hum+Hypertens 2016 ; 30 (6): 368-73
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  • Screening for non-adherence to antihypertensive treatment as a part of the diagnostic pathway to renal denervation #MMPMID26446393
  • Patel P; Gupta PKC; White CMJ; Stanley AG; Williams B; Tomaszewski M
  • J Hum Hypertens 2016[Jun]; 30 (6): 368-73 PMID26446393show ga
  • Renal denervation is a potential therapeutic option for resistant hypertension. A thorough clinical assessment to exclude reversible/spurious causes of resistance to antihypertensive therapy is required prior to this procedure. The extent to which non-adherence to antihypertensive treatment contributes to apparent resistance to antihypertensive therapy in patients considered for renal denervation is not known. Patients (n=34) referred for renal denervation entered the evaluation pathway that included screening for adherence to antihypertensive treatment by high-performance liquid chromatography-tandem mass spectrometry-based urine analysis. Biochemical non-adherence to antihypertensive treatment was the most common cause of non-eligibility for renal denervation?23.5% of patients were either partially or completely non-adherent to prescribed antihypertensive treatment. About 5.9% of those referred for renal denervation had admitted non-adherence prior to performing the screening test. Suboptimal pharmacological treatment of hypertension and ?white-coat effect' accounted for apparently resistant hypertension in a further 17.7 and 5.9% of patients, respectively. Taken together, these three causes of pseudo-resistant hypertension accounted for 52.9% of patients referred for renal denervation. Only 14.7% of referred patients were ultimately deemed eligible for renal denervation. Without biochemical screening for therapeutic non-adherence, the eligibility rate for renal denervation would have been 38.2%. Non-adherence to antihypertensive treatment and other forms of therapeutic pseudo-resistance are by far the most common reason of ?resistant hypertension' in patients referred for renal denervation. We suggest that inclusion of biochemical screening for non-adherence to antihypertensive treatment may be helpful in evaluation of patients with ?resistant hypertension' prior to consideration of renal denervation.
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