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10.1016/j.ebiom.2016.02.028 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2016.02.028 C4856749!4856749!27211549     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2016 ; 6 (ä): 59-72 Nephropedia Template TP {{tp|p=27211549|t=2016. The Nuclear Receptor, ROR?, Regulates Pathways Necessary for Breast Cancer Metastasis |pdf=|usr=}}{{27211549}} gab.com Text The Nuclear Receptor, ROR , Regulates Pathways Necessary for Breast Cancer Metastasis JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=27211549 #FOAvip We have previously reported that ROR? expression was decreased in ER ? ve breast cancer, and increased expression improves clinical outcomes. However, the underlying ROR? dependent mechanisms that repress breast carcinogenesis have not been elucidated. Here we report that ROR? negatively regulates the oncogenic TGF-?/EMT and mammary stem cell (MaSC) pathways, whereas ROR? positively regulates DNA-repair. We demonstrate that ROR? expression is: (i) decreased in basal-like subtype cancers, and (ii) inversely correlated with histological grade and drivers of carcinogenesis in breast cancer cohorts. Furthermore, integration of RNA-seq and ChIP-chip data reveals that ROR? regulates the expression of many genes involved in TGF-?/EMT-signaling, DNA-repair and MaSC pathways (including the non-coding RNA, LINC00511). In accordance, pharmacological studies demonstrate that an ROR? agonist suppresses breast cancer cell viability, migration, the EMT transition (microsphere outgrowth) and mammosphere-growth. In contrast, RNA-seq demonstrates an ROR? inverse agonist induces TGF-?/EMT-signaling. These findings suggest pharmacological modulation of ROR? activity may have utility in breast cancer. Twit Text FOAVip The Nuclear Receptor, ROR , Regulates Pathways Necessary for Breast Cancer Metastasis ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=27211549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27211549 #FOAvip English Wikipedia <ref>{{Cite pmid|27211549}}</ref> The Nuclear Receptor, ROR?, Regulates Pathways Necessary for Breast Cancer Metastasis #MMPMID27211549 Oh TG; Wang SCM; Acharya BR; Goode JM; Graham JD; Clarke CL; Yap AS; Muscat GE EBioMedicine 2016[Apr]; 6 (ä): 59-72 PMID27211549show ga We have previously reported that ROR? expression was decreased in ER ? ve breast cancer, and increased expression improves clinical outcomes. However, the underlying ROR? dependent mechanisms that repress breast carcinogenesis have not been elucidated. Here we report that ROR? negatively regulates the oncogenic TGF-?/EMT and mammary stem cell (MaSC) pathways, whereas ROR? positively regulates DNA-repair. We demonstrate that ROR? expression is: (i) decreased in basal-like subtype cancers, and (ii) inversely correlated with histological grade and drivers of carcinogenesis in breast cancer cohorts. Furthermore, integration of RNA-seq and ChIP-chip data reveals that ROR? regulates the expression of many genes involved in TGF-?/EMT-signaling, DNA-repair and MaSC pathways (including the non-coding RNA, LINC00511). In accordance, pharmacological studies demonstrate that an ROR? agonist suppresses breast cancer cell viability, migration, the EMT transition (microsphere outgrowth) and mammosphere-growth. In contrast, RNA-seq demonstrates an ROR? inverse agonist induces TGF-?/EMT-signaling. These findings suggest pharmacological modulation of ROR? activity may have utility in breast cancer. äThe Nuclear Receptor, ROR?, Regulates Pathways Necessary for Breast Ca(epmc).pdf DeepDyve Pubget Overpricing