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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 EBioMedicine 2016 ; 6 (ä): 199-205 Nephropedia Template TP
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Risk of Stroke in Migraineurs Using Triptans Associations with Age, Sex, Stroke Severity and Subtype #MMPMID27211561
Albieri V; Olsen TS; Andersen KK
EBioMedicine 2016[Apr]; 6 (ä): 199-205 PMID27211561show ga
Background: Identifying migraineurs by triptan utilization we studied risk for stroke in migraineurs compared to the general population. Methods: A cohort study including all citizens 25?80 years of age in Denmark 2003?2011 was conducted. All persons prescribed triptans, and all those hospitalized for a first stroke were identified in the Danish Registries. Information on stroke severity/subtype and cardiovascular risk factors was available for stroke patients. Findings: Of the 49,711 patients hospitalized for a first stroke, 1084 were migraineurs using triptans. Adjusting for age, sex, income, and educational level, risk for stroke was higher among migraineurs in respect to all strokes (RR 1.07; CI 1.01?1.14) and ischemic strokes (RR 1.07; CI 1.00?1.14). Risk for hemorrhagic stroke was increased but only in women (RR 1.41; CI 1.11?1.79). Risk was for mild strokes (RR 1.31; CI 1.16?1.48) while risk for severe strokes was lower among migraineurs (RR 0.77; CI 0.65?0.91). Risk was age-related; highest among women 25?45 years (RR ? 1.7). Risk was unrelated to numbers of dispensations. Interpretation: Migraineurs identified by triptan utilization had higher risk for stroke. Strokes were minor and cardiovascular risk factors were less prevalent pointing to a migraine-specific etiology of stroke different from that of thromboembolism.