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2016 ; 6
(ä): 199-205
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Risk of Stroke in Migraineurs Using Triptans Associations with Age, Sex, Stroke
Severity and Subtype
#MMPMID27211561
Albieri V
; Olsen TS
; Andersen KK
EBioMedicine
2016[Apr]; 6
(ä): 199-205
PMID27211561
show ga
BACKGROUND: Identifying migraineurs by triptan utilization we studied risk for
stroke in migraineurs compared to the general population. METHODS: A cohort study
including all citizens 25-80years of age in Denmark 2003-2011 was conducted. All
persons prescribed triptans, and all those hospitalized for a first stroke were
identified in the Danish Registries. Information on stroke severity/subtype and
cardiovascular risk factors was available for stroke patients. FINDINGS: Of the
49,711 patients hospitalized for a first stroke, 1084 were migraineurs using
triptans. Adjusting for age, sex, income, and educational level, risk for stroke
was higher among migraineurs in respect to all strokes (RR 1.07; CI 1.01-1.14)
and ischemic strokes (RR 1.07; CI 1.00-1.14). Risk for hemorrhagic stroke was
increased but only in women (RR 1.41; CI 1.11-1.79). Risk was for mild strokes
(RR 1.31; CI 1.16-1.48) while risk for severe strokes was lower among migraineurs
(RR 0.77; CI 0.65-0.91). Risk was age-related; highest among women 25-45years
(RR?1.7). Risk was unrelated to numbers of dispensations. INTERPRETATION:
Migraineurs identified by triptan utilization had higher risk for stroke. Strokes
were minor and cardiovascular risk factors were less prevalent pointing to a
migraine-specific etiology of stroke different from that of thromboembolism.
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Denmark/epidemiology
[MESH]
|Female
[MESH]
|Hospitalization/statistics & numerical data
[MESH]