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10.1016/j.ebiom.2016.02.039

http://scihub22266oqcxt.onion/10.1016/j.ebiom.2016.02.039
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C4856739!4856739 !27211561
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suck abstract from ncbi


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pmid27211561
      EBioMedicine 2016 ; 6 (ä): 199-205
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  • Risk of Stroke in Migraineurs Using Triptans Associations with Age, Sex, Stroke Severity and Subtype #MMPMID27211561
  • Albieri V ; Olsen TS ; Andersen KK
  • EBioMedicine 2016[Apr]; 6 (ä): 199-205 PMID27211561 show ga
  • BACKGROUND: Identifying migraineurs by triptan utilization we studied risk for stroke in migraineurs compared to the general population. METHODS: A cohort study including all citizens 25-80years of age in Denmark 2003-2011 was conducted. All persons prescribed triptans, and all those hospitalized for a first stroke were identified in the Danish Registries. Information on stroke severity/subtype and cardiovascular risk factors was available for stroke patients. FINDINGS: Of the 49,711 patients hospitalized for a first stroke, 1084 were migraineurs using triptans. Adjusting for age, sex, income, and educational level, risk for stroke was higher among migraineurs in respect to all strokes (RR 1.07; CI 1.01-1.14) and ischemic strokes (RR 1.07; CI 1.00-1.14). Risk for hemorrhagic stroke was increased but only in women (RR 1.41; CI 1.11-1.79). Risk was for mild strokes (RR 1.31; CI 1.16-1.48) while risk for severe strokes was lower among migraineurs (RR 0.77; CI 0.65-0.91). Risk was age-related; highest among women 25-45years (RR?1.7). Risk was unrelated to numbers of dispensations. INTERPRETATION: Migraineurs identified by triptan utilization had higher risk for stroke. Strokes were minor and cardiovascular risk factors were less prevalent pointing to a migraine-specific etiology of stroke different from that of thromboembolism.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Denmark/epidemiology [MESH]
  • |Female [MESH]
  • |Hospitalization/statistics & numerical data [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Migraine Disorders/complications/*drug therapy [MESH]
  • |Prevalence [MESH]
  • |Prospective Studies [MESH]
  • |Risk Factors [MESH]
  • |Stroke/chemically induced/*classification/*epidemiology [MESH]


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