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10.1038/nrc2734 http://scihub22266oqcxt.onion/10.1038/nrc2734 C4856025!4856025!19851315     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19851315&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Cancer 2009 ; 9 (11): 798-809 Nephropedia Template TP {{tp|p=19851315|t=2009. STATs in cancer inflammation and immunity: a leading role for STAT3 |pdf=|usr=}}{{19851315}} gab.com Text STATs in cancer inflammation and immunity: a leading role for STAT3 JO: Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=19851315 #FOAvip Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-?B (NF-?B) and interleukin-6 (IL-6)?GP130?Janus kinase (JAK) pathways, and by opposing STAT1- and NF-?B-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy. Twit Text FOAVip STATs in cancer inflammation and immunity: a leading role for STAT3 ????Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=19851315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19851315 #FOAvip English Wikipedia <ref>{{Cite pmid|19851315}}</ref> STATs in cancer inflammation and immunity: a leading role for STAT3 #MMPMID19851315 Yu H; Pardoll D; Jove R Nat Rev Cancer 2009[Nov]; 9 (11): 798-809 PMID19851315show ga Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-?B (NF-?B) and interleukin-6 (IL-6)?GP130?Janus kinase (JAK) pathways, and by opposing STAT1- and NF-?B-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy. äSTATs in cancer inflammation and immunity: a leading role for STAT3 (epmc).pdf DeepDyve Pubget Overpricing