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10.1172/JCI84547 http://scihub22266oqcxt.onion/10.1172/JCI84547 C4855927!4855927!27135879     free     free     free       J+Clin+Invest ä ; 126 (5): 1621-9 Nephropedia Template TP {{tp|p=27135879|t=ä. The shelterin complex and hematopoiesis |pdf=|usr=}}{{27135879}} gab.com Text The shelterin complex and hematopoiesis JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27135879 #FOAvip Mammalian chromosomes terminate in stretches of repetitive telomeric DNA that act as buffers to avoid loss of essential genetic information during end-replication. A multiprotein complex known as shelterin prevents recognition of telomeric sequences as sites of DNA damage. Telomere erosion contributes to human diseases ranging from BM failure to premature aging syndromes and cancer. The role of shelterin telomere protection is less understood. Mutations in genes encoding the shelterin proteins TRF1-interacting nuclear factor 2 (TIN2) and adrenocortical dysplasia homolog (ACD) were identified in dyskeratosis congenita, a syndrome characterized by somatic stem cell dysfunction in multiple organs leading to BM failure and other pleiotropic manifestations. Here, we introduce the biochemical features and in vivo effects of individual shelterin proteins, discuss shelterin functions in hematopoiesis, and review emerging knowledge implicating the shelterin complex in hematological disorders. Twit Text FOAVip The shelterin complex and hematopoiesis ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27135879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27135879 #FOAvip English Wikipedia <ref>{{Cite pmid|27135879}}</ref> The shelterin complex and hematopoiesis #MMPMID27135879 Jones M; Bisht K; Savage SA; Nandakumar J; Keegan CE; Maillard I J Clin Invest ä[]; 126 (5): 1621-9 PMID27135879show ga Mammalian chromosomes terminate in stretches of repetitive telomeric DNA that act as buffers to avoid loss of essential genetic information during end-replication. A multiprotein complex known as shelterin prevents recognition of telomeric sequences as sites of DNA damage. Telomere erosion contributes to human diseases ranging from BM failure to premature aging syndromes and cancer. The role of shelterin telomere protection is less understood. Mutations in genes encoding the shelterin proteins TRF1-interacting nuclear factor 2 (TIN2) and adrenocortical dysplasia homolog (ACD) were identified in dyskeratosis congenita, a syndrome characterized by somatic stem cell dysfunction in multiple organs leading to BM failure and other pleiotropic manifestations. Here, we introduce the biochemical features and in vivo effects of individual shelterin proteins, discuss shelterin functions in hematopoiesis, and review emerging knowledge implicating the shelterin complex in hematological disorders. äThe shelterin complex and hematopoiesis (epmc).pdf DeepDyve Pubget Overpricing