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10.1039/c6cc02282k http://scihub22266oqcxt.onion/10.1039/c6cc02282k C4855835!4855835 !27087169     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27087169 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Chem+Commun+(Camb) 2016 ; 52 (37 ): 6332-5 Nephropedia Template TP {{tp|p=27087169 |t=2016. Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells |pdf=|usr=}}{{27087169 }} gab.com Text Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells JO: Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=27087169 #FOAvip Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 ?M) towards an osteosarcoma cell line. Twit Text FOAVip Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells ????Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=27087169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27087169 #FOAvip English Wikipedia <ref>{{Cite pmid|27087169 }}</ref> Minimal C-terminal modification boosts peptide self-assembling ability for necroptosis of cancer cells #MMPMID27087169 Feng Z ; Wang H ; Du X ; Shi J ; Li J ; Xu B Chem Commun (Camb) 2016[May]; 52 (37 ): 6332-5 PMID27087169 show ga Here we reported the first case in which enhancing self-assembling ability boosts anti-cancer efficacy through a simple and minimal modification of the C-terminus of a d-tripeptide. By only a 2% change of the molecular weight, this facile approach increases the inhibitory activity by over an order of magnitude (IC50 from 431 to 23 ?M) towards an osteosarcoma cell line. |Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology [MESH] |Apoptosis/*drug effects [MESH] |Cell Line [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Screening Assays, Antitumor [MESH] |Humans [MESH] |Molecular Structure [MESH] |Molecular Weight [MESH] |Oligopeptides/chemical synthesis/chemistry/*pharmacology [MESH] |Osteosarcoma/*drug therapy/*pathology [MESH]Minimal C-terminal modification boosts peptide self-assembling ability(epmc).pdf DeepDyve Pubget Overpricing