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10.1038/cddis.2016.83 http://scihub22266oqcxt.onion/10.1038/cddis.2016.83 C4855662!4855662!27077809     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2016 ; 7 (4): e2193- Nephropedia Template TP {{tp|p=27077809|t=2016. A novel differentiation pathway from CD4+ T cells to CD4? T cells for maintaining immune system homeostasis |pdf=|usr=}}{{27077809}} gab.com Text A novel differentiation pathway from CD4+ T cells to CD4 T cells for maintaining immune system homeostasis JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27077809 #FOAvip CD4+ T lymphocytes are key players in the adaptive immune system and can differentiate into a variety of effector and regulatory T cells. Here, we provide evidence that a novel differentiation pathway of CD4+ T cells shifts the balance from a destructive T-cell response to one that favors regulation in an immune-mediated liver injury model. Peripheral CD4?CD8?NK1.1? double-negative T cells (DNT) was increased following Concanavalin A administration in mice. Adoptive transfer of DNT led to significant protection from hepatocyte necrosis by direct inhibition on the activation of lymphocytes, a process that occurred primarily through the perforin-granzyme B route. These DNT converted from CD4+ rather than CD8+ T cells, a process primarily regulated by OX40. DNT migrated to the liver through the CXCR3-CXCL9/CXCL10 interaction. In conclusion, we elucidated a novel differentiation pathway from activated CD4+ T cells to regulatory DNT cells for maintaining homeostasis of the immune system in vivo, and provided key evidence that utilizing this novel differentiation pathway has potential application in the prevention and treatment of autoimmune diseases. Twit Text FOAVip A novel differentiation pathway from CD4+ T cells to CD4 T cells for maintaining immune system homeostasis ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27077809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27077809 #FOAvip English Wikipedia <ref>{{Cite pmid|27077809}}</ref> A novel differentiation pathway from CD4+ T cells to CD4? T cells for maintaining immune system homeostasis #MMPMID27077809 Zhao X; Sun G; Sun X; Tian D; Liu K; Liu T; Cong M; Xu H; Li X; Shi W; Tian Y; Yao J; Guo H; Zhang D Cell Death Dis 2016[Apr]; 7 (4): e2193- PMID27077809show ga CD4+ T lymphocytes are key players in the adaptive immune system and can differentiate into a variety of effector and regulatory T cells. Here, we provide evidence that a novel differentiation pathway of CD4+ T cells shifts the balance from a destructive T-cell response to one that favors regulation in an immune-mediated liver injury model. Peripheral CD4?CD8?NK1.1? double-negative T cells (DNT) was increased following Concanavalin A administration in mice. Adoptive transfer of DNT led to significant protection from hepatocyte necrosis by direct inhibition on the activation of lymphocytes, a process that occurred primarily through the perforin-granzyme B route. These DNT converted from CD4+ rather than CD8+ T cells, a process primarily regulated by OX40. DNT migrated to the liver through the CXCR3-CXCL9/CXCL10 interaction. In conclusion, we elucidated a novel differentiation pathway from activated CD4+ T cells to regulatory DNT cells for maintaining homeostasis of the immune system in vivo, and provided key evidence that utilizing this novel differentiation pathway has potential application in the prevention and treatment of autoimmune diseases. äA novel differentiation pathway from CD4+ T cells to CD4? T cells for (epmc).pdf DeepDyve Pubget Overpricing