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10.1038/cddis.2016.101 http://scihub22266oqcxt.onion/10.1038/cddis.2016.101 C4855646!4855646!27124581     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2016 ; 7 (4): e2207- Nephropedia Template TP {{tp|p=27124581|t=2016. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing |pdf=|usr=}}{{27124581}} gab.com Text The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27124581 #FOAvip In this study, we identify signaling network of necrotic cell death induced by transcriptional repression (TRIAD) by ?-amanitin (AMA), the selective RNA polymerase II inhibitor, as a model of neurodegenerative cell death. We performed genetic screen of a knockdown (KD) fly library by measuring the ratio of transformation from pupa to larva (PL ratio) under TRIAD, and selected the cell death-promoting genes. Systems biology analysis of the positive genes mapped on protein?protein interaction databases predicted the signaling network of TRIAD and the core pathway including heterogeneous nuclear ribonucleoproteins (hnRNPs) and huntingtin (Htt). RNA sequencing revealed that AMA impaired transcription and RNA splicing of Htt, which is known as an endoplasmic reticulum (ER)-stabilizing molecule. The impairment in RNA splicing and PL ratio was rescued by overexpresion of hnRNP that had been also affected by transcriptional repression. Fly genetics with suppressor or expresser of Htt and hnRNP worsened or ameliorated the decreased PL ratio by AMA, respectively. Collectively, these results suggested involvement of RNA splicing and a regulatory role of the hnRNP-Htt axis in the process of the transcriptional repression-induced necrosis. Twit Text FOAVip The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=27124581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27124581 #FOAvip English Wikipedia <ref>{{Cite pmid|27124581}}</ref> The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing #MMPMID27124581 Mao Y; Tamura T; Yuki Y; Abe D; Tamada Y; Imoto S; Tanaka H; Homma H; Tagawa K; Miyano S; Okazawa H Cell Death Dis 2016[Apr]; 7 (4): e2207- PMID27124581show ga In this study, we identify signaling network of necrotic cell death induced by transcriptional repression (TRIAD) by ?-amanitin (AMA), the selective RNA polymerase II inhibitor, as a model of neurodegenerative cell death. We performed genetic screen of a knockdown (KD) fly library by measuring the ratio of transformation from pupa to larva (PL ratio) under TRIAD, and selected the cell death-promoting genes. Systems biology analysis of the positive genes mapped on protein?protein interaction databases predicted the signaling network of TRIAD and the core pathway including heterogeneous nuclear ribonucleoproteins (hnRNPs) and huntingtin (Htt). RNA sequencing revealed that AMA impaired transcription and RNA splicing of Htt, which is known as an endoplasmic reticulum (ER)-stabilizing molecule. The impairment in RNA splicing and PL ratio was rescued by overexpresion of hnRNP that had been also affected by transcriptional repression. Fly genetics with suppressor or expresser of Htt and hnRNP worsened or ameliorated the decreased PL ratio by AMA, respectively. Collectively, these results suggested involvement of RNA splicing and a regulatory role of the hnRNP-Htt axis in the process of the transcriptional repression-induced necrosis. äThe hnRNP-Htt axis regulates necrotic cell death induced by transcript(epmc).pdf DeepDyve Pubget Overpricing