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10.1073/pnas.1520010113 http://scihub22266oqcxt.onion/10.1073/pnas.1520010113 C4855596!4855596!27071093     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (17): E2373-82 Nephropedia Template TP {{tp|p=27071093|t=2016. The tandem duplicator phenotype as a distinct genomic configuration in cancer |pdf=|usr=}}{{27071093}} gab.com Text The tandem duplicator phenotype as a distinct genomic configuration in cancer JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27071093 #FOAvip In this study, we provide the first detailed molecular characterization, to our knowledge, of a distinct cancer genomic configuration, the tandem duplicator phenotype (TDP), that is significantly enriched in the molecularly related triple-negative breast, serous ovarian, and endometrial carcinomas. We show here that TDP represents an oncogenic configuration featuring (i) genome-wide disruption of cancer genes, (ii) loss of cell cycle control and DNA damage repair, and (iii) increased sensitivity to cisplatin chemotherapy both in vitro and in vivo. Therefore, the TDP is a systems strategy to achieve a protumorigenic genomic configuration by altering a large number of oncogenes and tumor suppressors. The TDP arises in a molecular context of joint genomic instability and replicative drive, and is consequently associated with enhanced sensitivity to cisplatin. Twit Text FOAVip The tandem duplicator phenotype as a distinct genomic configuration in cancer ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27071093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27071093 #FOAvip English Wikipedia <ref>{{Cite pmid|27071093}}</ref> The tandem duplicator phenotype as a distinct genomic configuration in cancer #MMPMID27071093 Menghi F; Inaki K; Woo X; Kumar PA; Grzeda KR; Malhotra A; Yadav V; Kim H; Marquez EJ; Ucar D; Shreckengast PT; Wagner JP; MacIntyre G; Murthy Karuturi KR; Scully R; Keck J; Chuang JH; Liu ET Proc Natl Acad Sci U S A 2016[Apr]; 113 (17): E2373-82 PMID27071093show ga In this study, we provide the first detailed molecular characterization, to our knowledge, of a distinct cancer genomic configuration, the tandem duplicator phenotype (TDP), that is significantly enriched in the molecularly related triple-negative breast, serous ovarian, and endometrial carcinomas. We show here that TDP represents an oncogenic configuration featuring (i) genome-wide disruption of cancer genes, (ii) loss of cell cycle control and DNA damage repair, and (iii) increased sensitivity to cisplatin chemotherapy both in vitro and in vivo. Therefore, the TDP is a systems strategy to achieve a protumorigenic genomic configuration by altering a large number of oncogenes and tumor suppressors. The TDP arises in a molecular context of joint genomic instability and replicative drive, and is consequently associated with enhanced sensitivity to cisplatin. äThe tandem duplicator phenotype as a distinct genomic configuration in(epmc).pdf DeepDyve Pubget Overpricing