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10.1172/jci.insight.83116 http://scihub22266oqcxt.onion/10.1172/jci.insight.83116 C4855513!4855513!27158671     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 1 (4): ä Nephropedia Template TP {{tp|p=27158671|t=ä. Vaccinia vaccine?based immunotherapy arrests and reverses established pulmonary fibrosis |pdf=|usr=}}{{27158671}} gab.com Text Vaccinia vaccine based immunotherapy arrests and reverses established pulmonary fibrosis JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27158671 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a fatal disease without any cure. Both human disease and animal models demonstrate dysregulated wound healing and unregulated fibrogenesis in a background of low-grade chronic T lymphocyte infiltration. Tissue-resident memory T cells (Trm) are emerging as important regulators of the immune microenvironment in response to pathogens, and we hypothesized that they might play a role in regulating the unremitting inflammation that promotes lung fibrosis. Herein, we demonstrate that lung-directed immunotherapy, in the form of i.n. vaccination, induces an antifibrotic T cell response capable of arresting and reversing lung fibrosis. In mice with established lung fibrosis, lung-specific T cell responses were able to reverse established pathology ? as measured by decreased lung collagen, fibrocytes, and histologic injury ? and improve physiologic function. Mechanistically, we demonstrate that this effect is mediated by vaccine-induced lung Trm. These data not only have implications for the development of immunotherapeutic regimens to treat IPF, but also suggest a role for targeting tissue-resident memory T cells to treat other tissue-specific inflammatory/autoimmune disorders. Twit Text FOAVip Vaccinia vaccine based immunotherapy arrests and reverses established pulmonary fibrosis ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=27158671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27158671 #FOAvip English Wikipedia <ref>{{Cite pmid|27158671}}</ref> Vaccinia vaccine?based immunotherapy arrests and reverses established pulmonary fibrosis #MMPMID27158671 Collins SL; Chan-Li Y; Oh M; Vigeland CL; Limjunyawong N; Mitzner W; Powell JD; Horton MR JCI Insight ä[]; 1 (4): ä PMID27158671show ga Idiopathic pulmonary fibrosis (IPF) is a fatal disease without any cure. Both human disease and animal models demonstrate dysregulated wound healing and unregulated fibrogenesis in a background of low-grade chronic T lymphocyte infiltration. Tissue-resident memory T cells (Trm) are emerging as important regulators of the immune microenvironment in response to pathogens, and we hypothesized that they might play a role in regulating the unremitting inflammation that promotes lung fibrosis. Herein, we demonstrate that lung-directed immunotherapy, in the form of i.n. vaccination, induces an antifibrotic T cell response capable of arresting and reversing lung fibrosis. In mice with established lung fibrosis, lung-specific T cell responses were able to reverse established pathology ? as measured by decreased lung collagen, fibrocytes, and histologic injury ? and improve physiologic function. Mechanistically, we demonstrate that this effect is mediated by vaccine-induced lung Trm. These data not only have implications for the development of immunotherapeutic regimens to treat IPF, but also suggest a role for targeting tissue-resident memory T cells to treat other tissue-specific inflammatory/autoimmune disorders. äVaccinia vaccine?based immunotherapy arrests and reverses established (epmc).pdf DeepDyve Pubget Overpricing