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10.1038/srep25226 http://scihub22266oqcxt.onion/10.1038/srep25226 C4855228!4855228 !27142962     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27142962 &cmd=llinks): Failed to open stream: HTTP request failed! 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Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-? 1-42 induced neurotoxicity and memory impairment |pdf=|usr=}}{{27142962 }} gab.com Text Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid- 1-42 induced neurotoxicity and memory impairment JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27142962 #FOAvip Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the main cause of dementia. Substantial evidences indicate that there is over-activation of the PI3K/Akt/mTOR axis in AD. Therefore, the aim of the present study was to investigate the effects of NVP-BEZ235 (BEZ; dactolisib), a dual PI3K/mTOR inhibitor that is under phase I/II clinical trials for the treatment of some types of cancer, in hippocampal neuronal cultures stimulated with amyloid-? (A?) 1-42 and in mice injected with A? 1-42 in the hippocampus. In cell cultures, BEZ reduced neuronal death induced by A?. BEZ, but not rapamycin, a mTOR inhibitor, or LY294002, a PI3K inhibitor that also inhibits mTOR, reduced the memory impairment induced by A?. The effect induced by A? was also prevented in PI3K?(-/-) mice. Neuronal death and microgliosis induced by A? were reduced by BEZ. In addition, the compound increased IL-10 and TNF-? levels in the hippocampus. Finally, BEZ did not change the phosphorylation of Akt and p70s6K, suggesting that the involvement of PI3K and mTOR in the effects induced by BEZ remains controversial. Therefore, BEZ represents a potential strategy to prevent the pathological outcomes induced by A? and should be investigated in other models of neurodegenerative conditions. Twit Text FOAVip Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid- 1-42 induced neurotoxicity and memory impairment ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27142962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27142962 #FOAvip English Wikipedia <ref>{{Cite pmid|27142962 }}</ref> Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-? 1-42 induced neurotoxicity and memory impairment #MMPMID27142962 Bellozi PM ; Lima IV ; Dória JG ; Vieira ÉL ; Campos AC ; Candelario-Jalil E ; Reis HJ ; Teixeira AL ; Ribeiro FM ; de Oliveira AC Sci Rep 2016[May]; 6 (ä): 25226 PMID27142962 show ga Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the main cause of dementia. Substantial evidences indicate that there is over-activation of the PI3K/Akt/mTOR axis in AD. Therefore, the aim of the present study was to investigate the effects of NVP-BEZ235 (BEZ; dactolisib), a dual PI3K/mTOR inhibitor that is under phase I/II clinical trials for the treatment of some types of cancer, in hippocampal neuronal cultures stimulated with amyloid-? (A?) 1-42 and in mice injected with A? 1-42 in the hippocampus. In cell cultures, BEZ reduced neuronal death induced by A?. BEZ, but not rapamycin, a mTOR inhibitor, or LY294002, a PI3K inhibitor that also inhibits mTOR, reduced the memory impairment induced by A?. The effect induced by A? was also prevented in PI3K?(-/-) mice. Neuronal death and microgliosis induced by A? were reduced by BEZ. In addition, the compound increased IL-10 and TNF-? levels in the hippocampus. Finally, BEZ did not change the phosphorylation of Akt and p70s6K, suggesting that the involvement of PI3K and mTOR in the effects induced by BEZ remains controversial. Therefore, BEZ represents a potential strategy to prevent the pathological outcomes induced by A? and should be investigated in other models of neurodegenerative conditions. |Amyloid beta-Peptides/*toxicity [MESH] |Animals [MESH] |Cell Survival/drug effects [MESH] |Cells, Cultured [MESH] |Hippocampus/*drug effects/*pathology [MESH] |Imidazoles/*administration & dosage/pharmacology [MESH] |Memory Disorders/*prevention & control [MESH] |Mice [MESH] |Neurons/drug effects/physiology [MESH] |Neuroprotective Agents/*administration & dosage/pharmacology [MESH]Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib)(epmc).pdf DeepDyve Pubget Overpricing