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10.1038/onc.2015.289 http://scihub22266oqcxt.onion/10.1038/onc.2015.289 C4855079!4855079!26257059     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2016 ; 35 (17): 2266-78 Nephropedia Template TP {{tp|p=26257059|t=2016. NKX6 1 functions as a metastatic suppressor through epigenetic regulation of the epithelial?mesenchymal transition |pdf=|usr=}}{{26257059}} gab.com Text NKX6 1 functions as a metastatic suppressor through epigenetic regulation of the epithelial mesenchymal transition JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26257059 #FOAvip The transcription factor NKX6.1 (NK6 homeobox 1) is important in the development of pancreatic ?-cells and neurons. Although recent publications show that NKX6.1 is hypermethylated and downregulated during tumorigenesis, the function of NKX6.1 in carcinogenesis remains elusive. Here, we address the metastasis suppressor function of human NKX6.1 using cell, animal and clinical analyses. Our data show that NKX6.1 represses tumor formation and metastatic ability both in vitro and in vivo. Mechanistically, NKX6.1 suppresses cell invasion by inhibiting the epithelial-to-mesenchymal transition (EMT). NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor. Clinical cancer tumors with metastasis show low NKX6.1 protein expression coinciding with low E-cadherin and high vimentin expression. Our results demonstrate that NKX6.1 functions as an EMT suppressor by interacting with different epigenetic modifiers, making it a potential novel therapeutic option. Twit Text FOAVip NKX6 1 functions as a metastatic suppressor through epigenetic regulation of the epithelial mesenchymal transition ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26257059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26257059 #FOAvip English Wikipedia <ref>{{Cite pmid|26257059}}</ref> NKX6 1 functions as a metastatic suppressor through epigenetic regulation of the epithelial?mesenchymal transition #MMPMID26257059 Li HJ; Yu PN; Huang KY; Su HY; Hsiao TH; Chang CP; Yu MH; Lin YW Oncogene 2016[Apr]; 35 (17): 2266-78 PMID26257059show ga The transcription factor NKX6.1 (NK6 homeobox 1) is important in the development of pancreatic ?-cells and neurons. Although recent publications show that NKX6.1 is hypermethylated and downregulated during tumorigenesis, the function of NKX6.1 in carcinogenesis remains elusive. Here, we address the metastasis suppressor function of human NKX6.1 using cell, animal and clinical analyses. Our data show that NKX6.1 represses tumor formation and metastatic ability both in vitro and in vivo. Mechanistically, NKX6.1 suppresses cell invasion by inhibiting the epithelial-to-mesenchymal transition (EMT). NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor. Clinical cancer tumors with metastasis show low NKX6.1 protein expression coinciding with low E-cadherin and high vimentin expression. Our results demonstrate that NKX6.1 functions as an EMT suppressor by interacting with different epigenetic modifiers, making it a potential novel therapeutic option. äNKX6 1 functions as a metastatic suppressor through epigenetic regulat(epmc).pdf DeepDyve Pubget Overpricing