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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Expo+Sci+Environ+Epidemiol
2016 ; 26
(5
): 452-7
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Contribution of breast milk and formula to arsenic exposure during the first year
of life in a US prospective cohort
#MMPMID26531802
Carignan CC
; Karagas MR
; Punshon T
; Gilbert-Diamond D
; Cottingham KL
J Expo Sci Environ Epidemiol
2016[Sep]; 26
(5
): 452-7
PMID26531802
show ga
Arsenic is a carcinogen that can also affect the cardiac, respiratory,
neurological and immune systems. Children have higher dietary arsenic exposure
than adults owing to their more restricted diets and greater intake per unit body
mass. We evaluated the potential contributions of breast milk and formula to
arsenic exposure throughout the first year of life for 356 infants in the
prospective New Hampshire Birth Cohort Study (NHBCS) using infant diets reported
by telephone at 4, 8 and 12 months of age; measured household water arsenic
concentrations; and literature data. Based on our central-tendency models,
population-wide geometric mean (GM) estimated arsenic exposures in the NHBCS were
relatively low, decreasing from 0.1??g/kg/day at 4 months of age to
0.07??g/kg/day at 12 months of age. At all three time points, exclusively
formula-fed infants had GM arsenic exposures ~8 times higher than exclusively
breastfed infants owing to arsenic in both tap water and formula powder.
Estimated maximum exposures reached 9??g/kg/day among exclusively formula-fed
infants in households with high tap water arsenic (80??g/l). Overall, modeled
arsenic exposures via breast milk and formula were low throughout the first year
of life, unless formula was prepared with arsenic-contaminated tap water.