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10.1158/1078-0432.CCR-15-1570 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-15-1570 C4854763!4854763!26979393     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Cancer+Res 2016 ; 22 (9): 2121-6 Nephropedia Template TP {{tp|p=26979393|t=2016. Molecular Pathways: Immunosuppressive Roles of IRE1??XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment |pdf=|usr=}}{{26979393}} gab.com Text Molecular Pathways: Immunosuppressive Roles of IRE1 XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26979393 #FOAvip The endoplasmic reticulum (ER) is a massive cytoplasmic membrane network that functions primarily to ensure proper folding and post-translational modification of newly synthesized secretory and transmembrane proteins. Abnormal accumulation of unfolded proteins in this organelle causes a state of ?ER stress?, which is a hallmark feature of various diseases including cancer, neurodegeneration and metabolic dysfunction. Cancer cells exploit the IRE1?-XBP1 arm of the ER stress response to efficiently adjust their protein-folding capacity and ensure survival under hostile tumor microenvironmental conditions. However, we recently found that dendritic cells (DCs) residing in the ovarian cancer microenvironment also experience sustained ER stress and demonstrate persistent activation of the IRE1?-XBP1 pathway. This previously unrecognized process disrupts metabolic homeostasis and antigen-presenting capacity in DCs, thereby crippling their natural ability to support the protective function of infiltrating anti-tumor T cells. In this review, we briefly discuss some of the mechanisms that fuel ER stress in tumor-associated DCs, the biological processes altered by aberrant IRE1?-XBP1 signaling in these innate immune cells, and the unique immunotherapeutic potential of targeting this pathway in cancer hosts. Twit Text FOAVip Molecular Pathways: Immunosuppressive Roles of IRE1 XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26979393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26979393 #FOAvip English Wikipedia <ref>{{Cite pmid|26979393}}</ref> Molecular Pathways: Immunosuppressive Roles of IRE1??XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment #MMPMID26979393 Cubillos-Ruiz JR; Bettigole SE; Glimcher LH Clin Cancer Res 2016[May]; 22 (9): 2121-6 PMID26979393show ga The endoplasmic reticulum (ER) is a massive cytoplasmic membrane network that functions primarily to ensure proper folding and post-translational modification of newly synthesized secretory and transmembrane proteins. Abnormal accumulation of unfolded proteins in this organelle causes a state of ?ER stress?, which is a hallmark feature of various diseases including cancer, neurodegeneration and metabolic dysfunction. Cancer cells exploit the IRE1?-XBP1 arm of the ER stress response to efficiently adjust their protein-folding capacity and ensure survival under hostile tumor microenvironmental conditions. However, we recently found that dendritic cells (DCs) residing in the ovarian cancer microenvironment also experience sustained ER stress and demonstrate persistent activation of the IRE1?-XBP1 pathway. This previously unrecognized process disrupts metabolic homeostasis and antigen-presenting capacity in DCs, thereby crippling their natural ability to support the protective function of infiltrating anti-tumor T cells. In this review, we briefly discuss some of the mechanisms that fuel ER stress in tumor-associated DCs, the biological processes altered by aberrant IRE1?-XBP1 signaling in these innate immune cells, and the unique immunotherapeutic potential of targeting this pathway in cancer hosts. äMolecular Pathways: Immunosuppressive Roles of IRE1??XBP1 Signaling in(epmc).pdf DeepDyve Pubget Overpricing