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Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition |pdf=|usr=}}{{27045007 }} gab.com Text Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27045007 #FOAvip Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were screened for reactivity against a panel of HLA-I molecules. This revealed different and distinct hierarchies of specificity for each KIR3DL1 allotype, with KIR3DL1*005 recognizing the widest array of HLA-I ligands. These differences were further reflected in functional studies using NK clones expressing these specific KIR3DL1 allotypes. Unexpectedly, the Ile/Thr80 dimorphism in the Bw4-motif did not categorically define strong/weak KIR3DL1 recognition. Although the KIR3DL1*001, *005, and *015 polymorphisms are remote from the KIR3DL1-HLA-I interface, the structures of these three KIR3DL1-HLA-I complexes showed that the broader HLA-I specificity of KIR3DL1*005 correlated with an altered KIR3DL1*005 interdomain positioning and increased mobility within its ligand-binding site. Collectively, we provide a generic framework for understanding the impact of KIR3DL1 polymorphism on the recognition of HLA-I allomorphs. Twit Text FOAVip Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27045007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27045007 #FOAvip English Wikipedia <ref>{{Cite pmid|27045007 }}</ref> Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition #MMPMID27045007 Saunders PM ; Pymm P ; Pietra G ; Hughes VA ; Hitchen C ; O'Connor GM ; Loiacono F ; Widjaja J ; Price DA ; Falco M ; Mingari MC ; Moretta L ; McVicar DW ; Rossjohn J ; Brooks AG ; Vivian JP J Exp Med 2016[May]; 213 (5 ): 791-807 PMID27045007 show ga Natural killer (NK) cells play a key role in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) polymorphism impacts disease outcome remains unclear. KIR3DL1 (*001/*005/*015) tetramers were screened for reactivity against a panel of HLA-I molecules. This revealed different and distinct hierarchies of specificity for each KIR3DL1 allotype, with KIR3DL1*005 recognizing the widest array of HLA-I ligands. These differences were further reflected in functional studies using NK clones expressing these specific KIR3DL1 allotypes. Unexpectedly, the Ile/Thr80 dimorphism in the Bw4-motif did not categorically define strong/weak KIR3DL1 recognition. Although the KIR3DL1*001, *005, and *015 polymorphisms are remote from the KIR3DL1-HLA-I interface, the structures of these three KIR3DL1-HLA-I complexes showed that the broader HLA-I specificity of KIR3DL1*005 correlated with an altered KIR3DL1*005 interdomain positioning and increased mobility within its ligand-binding site. Collectively, we provide a generic framework for understanding the impact of KIR3DL1 polymorphism on the recognition of HLA-I allomorphs. |*Polymorphism, Genetic [MESH] |Amino Acid Motifs [MESH] |Cell Line [MESH] |Female [MESH] |Histocompatibility Antigens Class I/chemistry/*genetics/*immunology [MESH] |Humans [MESH] |Killer Cells, Natural/chemistry/immunology [MESH] |Male [MESH]Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines dis(epmc).pdf DeepDyve Pubget Overpricing