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10.1084/jem.20151876

http://scihub22266oqcxt.onion/10.1084/jem.20151876
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C4854735!4854735!27091841
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suck abstract from ncbi


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pmid27091841      J+Exp+Med 2016 ; 213 (5): 697-713
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  • Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus #MMPMID27091841
  • Caielli S; Athale S; Domic B; Murat E; Chandra M; Banchereau R; Baisch J; Phelps K; Clayton S; Gong M; Wright T; Punaro M; Palucka K; Guiducci C; Banchereau J; Pascual V
  • J Exp Med 2016[May]; 213 (5): 697-713 PMID27091841show ga
  • As an alternative to mitophagy, neutrophils spontaneously extrude mitochondrial (mt) DNA devoid of oxidized residues (Ox). Activated lupus neutrophils or healthy neutrophils treated with IFN/?RNP release ox-mtDNA bound to TFAM, which induces high levels of IFN-? in pDCs.
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