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10.1084/jem.20151790

http://scihub22266oqcxt.onion/10.1084/jem.20151790
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C4854733!4854733!27069117
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suck abstract from ncbi


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pmid27069117      J+Exp+Med 2016 ; 213 (5): 771-90
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  • A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly #MMPMID27069117
  • Schmidt FI; Lu A; Chen JW; Ruan J; Tang C; Wu H; Ploegh HL
  • J Exp Med 2016[May]; 213 (5): 771-90 PMID27069117show ga
  • Ploegh et al. raised an alpaca single-domain antibody (VHH) against the inflammasome adaptor ASC. VHHASC blocks inflammasome activation in vitro and in living cells, and demonstrates a role of the ASC CARD domain in cross-linking ASC Pyrin domain filaments.
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