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10.1084/jem.20151722 http://scihub22266oqcxt.onion/10.1084/jem.20151722 C4854731!4854731 !27069112     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27069112 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (5 ): 715-32 Nephropedia Template TP {{tp|p=27069112 |t=2016. IFN-? receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity |pdf=|usr=}}{{27069112 }} gab.com Text IFN- receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27069112 #FOAvip Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to promote autoimmunity. However, the mechanisms that regulate Spt-GC development are not clear. In this study, we report that B cell-intrinsic IFN-? receptor (IFN-?R) and STAT1 signaling are required for Spt-GC and follicular T helper cell (Tfh cell) development. We further demonstrate that IFN-?R and STAT1 signaling control Spt-GC and Tfh cell formation by driving T-bet expression and IFN-? production by B cells. Global or B cell-specific IFN-?R deficiency in autoimmune B6.Sle1b mice leads to significantly reduced Spt-GC and Tfh cell responses, resulting in diminished antinuclear Ab reactivity and IgG2c and IgG2b auto-Ab titers compared with B6.Sle1b mice. Additionally, we observed that the proliferation and differentiation of DNA-reactive B cells into a GC B cell phenotype require B cell-intrinsic IFN-?R signaling, suggesting that IFN-?R signaling regulates GC B cell tolerance to nuclear self-antigens. The IFN-?R deficiency, however, does not affect GC, Tfh cell, or Ab responses against T cell-dependent foreign antigens, indicating that IFN-?R signaling regulates autoimmune, but not the foreign antigen-driven, GC and Tfh cell responses. Together, our data define a novel B cell-intrinsic IFN-?R signaling pathway specific to Spt-GC development and autoimmunity. This novel pathway can be targeted for future pharmacological intervention to treat systemic lupus erythematosus. Twit Text FOAVip IFN- receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27069112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27069112 #FOAvip English Wikipedia <ref>{{Cite pmid|27069112 }}</ref> IFN-? receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity #MMPMID27069112 Domeier PP ; Chodisetti SB ; Soni C ; Schell SL ; Elias MJ ; Wong EB ; Cooper TK ; Kitamura D ; Rahman ZS J Exp Med 2016[May]; 213 (5 ): 715-32 PMID27069112 show ga Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to promote autoimmunity. However, the mechanisms that regulate Spt-GC development are not clear. In this study, we report that B cell-intrinsic IFN-? receptor (IFN-?R) and STAT1 signaling are required for Spt-GC and follicular T helper cell (Tfh cell) development. We further demonstrate that IFN-?R and STAT1 signaling control Spt-GC and Tfh cell formation by driving T-bet expression and IFN-? production by B cells. Global or B cell-specific IFN-?R deficiency in autoimmune B6.Sle1b mice leads to significantly reduced Spt-GC and Tfh cell responses, resulting in diminished antinuclear Ab reactivity and IgG2c and IgG2b auto-Ab titers compared with B6.Sle1b mice. Additionally, we observed that the proliferation and differentiation of DNA-reactive B cells into a GC B cell phenotype require B cell-intrinsic IFN-?R signaling, suggesting that IFN-?R signaling regulates GC B cell tolerance to nuclear self-antigens. The IFN-?R deficiency, however, does not affect GC, Tfh cell, or Ab responses against T cell-dependent foreign antigens, indicating that IFN-?R signaling regulates autoimmune, but not the foreign antigen-driven, GC and Tfh cell responses. Together, our data define a novel B cell-intrinsic IFN-?R signaling pathway specific to Spt-GC development and autoimmunity. This novel pathway can be targeted for future pharmacological intervention to treat systemic lupus erythematosus. |Animals [MESH] |Autoantibodies/immunology [MESH] |B-Lymphocytes/*immunology/pathology [MESH] |Germinal Center/*immunology/pathology [MESH] |Interferon gamma Receptor [MESH] |Lupus Erythematosus, Systemic/genetics/*immunology/pathology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Receptors, Interferon/genetics/*immunology [MESH] |STAT1 Transcription Factor/genetics/*immunology [MESH] |Signal Transduction/genetics/*immunology [MESH]IFN-? receptor and STAT1 signaling in B cells are central to spontaneo(epmc).pdf DeepDyve Pubget Overpricing