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10.1084/jem.20151208

http://scihub22266oqcxt.onion/10.1084/jem.20151208
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C4854728!4854728!27091842
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suck abstract from ncbi


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pmid27091842      J+Exp+Med 2016 ; 213 (5): 859-75
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  • Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma #MMPMID27091842
  • Yang C; Tan Yx; Yang Gz; Zhang J; Pan Yf; Liu C; Fu J; Chen Y; Ding Zw; Dong Lw; Wang Hy
  • J Exp Med 2016[May]; 213 (5): 859-75 PMID27091842show ga
  • Yang et al. identify a feedback loop between gankyrin, an oncoprotein overexpressed in human hepatocellular carcinoma (HCC), and Nrf2. The positive feedback modulates a series of antioxidant enzymes that lower intracellular reactive oxygen species to confer protection from mitochondrial damage and cell death.
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