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10.1080/15548627.2016.1157242 http://scihub22266oqcxt.onion/10.1080/15548627.2016.1157242 C4854543!4854543 !27028978     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27028978 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27028978 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autophagy 2016 ; 12 (5 ): 888-9 Nephropedia Template TP {{tp|p=27028978 |t=2016. Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease |pdf=|usr=}}{{27028978 }} gab.com Text Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27028978 #FOAvip Intracellular swelling of conidia of the major human airborne fungal pathogen Aspergillus fumigatus results in surface exposure of immunostimulatory pathogen-associated molecular patterns (PAMPs) and triggers activation of a specialized autophagy pathway called LC3-associated phagocytosis (LAP) to promote fungal killing. We have recently discovered that, apart from PAMPs exposure, cell wall melanin removal during germination of A. fumigatus is a prerequisite for activation of LAP. Importantly, melanin promotes fungal pathogenicity via targeting LAP, as a melanin-deficient A. fumigatus mutant restores its virulence upon conditional inactivation of Atg5 in hematopoietic cells of mice. Mechanistically, fungal cell wall melanin selectively excludes the CYBA/p22phox subunit of NADPH oxidase from the phagosome to inhibit LAP, without interfering with signaling regulating cytokine responses. Notably, inhibition of LAP is a general property of melanin pigments, a finding with broad physiological implications. Twit Text FOAVip Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27028978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27028978 #FOAvip English Wikipedia <ref>{{Cite pmid|27028978 }}</ref> Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease #MMPMID27028978 Chamilos G ; Akoumianaki T ; Kyrmizi I ; Brakhage A ; Beauvais A ; Latge JP Autophagy 2016[May]; 12 (5 ): 888-9 PMID27028978 show ga Intracellular swelling of conidia of the major human airborne fungal pathogen Aspergillus fumigatus results in surface exposure of immunostimulatory pathogen-associated molecular patterns (PAMPs) and triggers activation of a specialized autophagy pathway called LC3-associated phagocytosis (LAP) to promote fungal killing. We have recently discovered that, apart from PAMPs exposure, cell wall melanin removal during germination of A. fumigatus is a prerequisite for activation of LAP. Importantly, melanin promotes fungal pathogenicity via targeting LAP, as a melanin-deficient A. fumigatus mutant restores its virulence upon conditional inactivation of Atg5 in hematopoietic cells of mice. Mechanistically, fungal cell wall melanin selectively excludes the CYBA/p22phox subunit of NADPH oxidase from the phagosome to inhibit LAP, without interfering with signaling regulating cytokine responses. Notably, inhibition of LAP is a general property of melanin pigments, a finding with broad physiological implications. |Animals [MESH] |Aspergillus fumigatus [MESH] |Humans [MESH] |Melanins/*metabolism [MESH] |Mycoses/*metabolism/microbiology [MESH] |Phagocytosis/*physiology [MESH]Melanin targets LC3-associated phagocytosis (LAP): A novel pathogeneti(epmc).pdf DeepDyve Pubget Overpricing