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10.7554/eLife.12190 http://scihub22266oqcxt.onion/10.7554/eLife.12190 C4854514!4854514!27138195     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27138195|t=2016. A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission |pdf=|usr=}}{{27138195}} gab.com Text A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27138195 #FOAvip Excitability differs among muscle fibers and undergoes continuous changes during development and growth, yet the neuromuscular synapse maintains a remarkable fidelity of execution. Here we show in two evolutionarily distant vertebrates (Xenopus laevis cell culture and mouse nerve-muscle ex-vivo) that the skeletal muscle cell constantly senses, through two identified calcium signals, synaptic events and their efficacy in eliciting spikes. These sensors trigger retrograde signal(s) that control presynaptic neurotransmitter release, resulting in synaptic potentiation or depression. In the absence of spikes, synaptic events trigger potentiation. Once the synapse is sufficiently strong to initiate spiking, the occurrence of these spikes activates a negative retrograde feedback. These opposing signals dynamically balance the synapse in order to continuously adjust neurotransmitter release to a level matching current muscle cell excitability.DOI:http://dx.doi.org/10.7554/eLife.12190.001 Twit Text FOAVip A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27138195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27138195 #FOAvip English Wikipedia <ref>{{Cite pmid|27138195}}</ref> A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission #MMPMID27138195 Ouanounou G; Baux G; Bal T eLife 2016[]; 5 (ä): ä PMID27138195show ga Excitability differs among muscle fibers and undergoes continuous changes during development and growth, yet the neuromuscular synapse maintains a remarkable fidelity of execution. Here we show in two evolutionarily distant vertebrates (Xenopus laevis cell culture and mouse nerve-muscle ex-vivo) that the skeletal muscle cell constantly senses, through two identified calcium signals, synaptic events and their efficacy in eliciting spikes. These sensors trigger retrograde signal(s) that control presynaptic neurotransmitter release, resulting in synaptic potentiation or depression. In the absence of spikes, synaptic events trigger potentiation. Once the synapse is sufficiently strong to initiate spiking, the occurrence of these spikes activates a negative retrograde feedback. These opposing signals dynamically balance the synapse in order to continuously adjust neurotransmitter release to a level matching current muscle cell excitability.DOI:http://dx.doi.org/10.7554/eLife.12190.001 äA novel synaptic plasticity rule explains homeostasis of neuromuscular(epmc).pdf DeepDyve Pubget Overpricing