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Conflict of interest disclosure in biomedical research: A review of current
practices, biases, and the role of public registries in improving transparency
#MMPMID27158530
Dunn AG
; Coiera E
; Mandl KD
; Bourgeois FT
Res Integr Peer Rev
2016[]; 1
(?): ? PMID27158530
show ga
Conflicts of interest held by researchers remain a focus of attention in clinical
research. Biases related to these relationships have the potential to directly
impact the quality of healthcare by influencing decision-making, yet conflicts of
interest remain under-reported, inconsistently described, and difficult to
access. Initiatives aimed at improving the disclosure of researcher conflicts of
interest are still in their infancy but represent a vital reform that must be
addressed before potential biases associated with conflicts of interest can be
mitigated, and trust in the impartiality of clinical evidence restored. In this
review, we examine the prevalence of conflicts of interest, evidence of the
effects that disclosed and undisclosed conflicts of interest have had on the
reporting of clinical evidence, and the emerging approaches for improving the
completeness and consistency of disclosures. Through this review of emerging
technologies, we recognize a growing interest in publicly-accessible registries
for researcher conflicts of interest, and propose five desiderata aimed at
maximizing the value of such registries: mandates for ensuring that researchers
keep their records up to date; transparent records that are made available to the
public; interoperability to allow researchers, bibliographic databases, and
institutions to interact with the registry; a consistent taxonomy for describing
different classes of conflicts of interest, and the ability to automatically
generate conflicts of interest statements for use in published articles.
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