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10.1126/science.aaa8064 http://scihub22266oqcxt.onion/10.1126/science.aaa8064 C4854322!4854322!26185250     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 349 (6245): 316-20 Nephropedia Template TP {{tp|p=26185250|t=2015. Neutrophil extracellular traps license macrophages and Th17 cells for cytokine production in atherosclerosis |pdf=|usr=}}{{26185250}} gab.com Text Neutrophil extracellular traps license macrophages and Th17 cells for cytokine production in atherosclerosis JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26185250 #FOAvip Secretion of the cytokine interleukin-1? (IL-1?) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps. First, priming signals promote transcription of immature IL-1? and then, endogenous ?danger? signals activate innate immune signaling complexes called inflammasomes, to process IL-1? processing for secretion. While cholesterol crystals act as danger signals in atherosclerosis, what primes IL-1? transcription remains elusive. Using a murine model of atherosclerosis, we show that cholesterol crystals acted both as priming and danger signals for IL-1? production. Cholesterol crystals triggered neutrophils to release neutrophil extracellular traps (NETs). NETs primed macrophages for cytokine release, activating Th-17 cells that amplify immune cell recruitment in atherosclerotic plaques. Therefore, danger signals may drive sterile inflammation, such as that seen in atherosclerosis, through their interactions with neutrophils. Twit Text FOAVip Neutrophil extracellular traps license macrophages and Th17 cells for cytokine production in atherosclerosis ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26185250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26185250 #FOAvip English Wikipedia <ref>{{Cite pmid|26185250}}</ref> Neutrophil extracellular traps license macrophages and Th17 cells for cytokine production in atherosclerosis #MMPMID26185250 Warnatsch A; Ioannou M; Wang Q; Papayannopoulos V Science 2015[Jul]; 349 (6245): 316-20 PMID26185250show ga Secretion of the cytokine interleukin-1? (IL-1?) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps. First, priming signals promote transcription of immature IL-1? and then, endogenous ?danger? signals activate innate immune signaling complexes called inflammasomes, to process IL-1? processing for secretion. While cholesterol crystals act as danger signals in atherosclerosis, what primes IL-1? transcription remains elusive. Using a murine model of atherosclerosis, we show that cholesterol crystals acted both as priming and danger signals for IL-1? production. Cholesterol crystals triggered neutrophils to release neutrophil extracellular traps (NETs). NETs primed macrophages for cytokine release, activating Th-17 cells that amplify immune cell recruitment in atherosclerotic plaques. Therefore, danger signals may drive sterile inflammation, such as that seen in atherosclerosis, through their interactions with neutrophils. äNeutrophil extracellular traps license macrophages and Th17 cells for (epmc).pdf DeepDyve Pubget Overpricing