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10.2147/OTT.S102422 http://scihub22266oqcxt.onion/10.2147/OTT.S102422 C4854234!4854234 !27175085     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27175085 &cmd=llinks): Failed to open stream: HTTP request failed! 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Paeoniflorin prevents hypoxia-induced epithelial-mesenchymal transition in human breast cancer cells |pdf=|usr=}}{{27175085 }} gab.com Text Paeoniflorin prevents hypoxia-induced epithelial-mesenchymal transition in human breast cancer cells JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=27175085 #FOAvip Paeoniflorin (PF) is a monoterpene glycoside extracted from the root of Paeonia lactiflora Pall. Previous studies have demonstrated that PF inhibits the growth, invasion, and metastasis of tumors in vivo and in vitro. However, the effect of PF on hypoxia-induced epithelial-mesenchymal transition (EMT) in breast cancer cells remains unknown. Therefore, the objective of this study was to investigate the effect of PF on hypoxia-induced EMT in breast cancer cells, as well as characterize the underlying mechanism. The results presented in this study demonstrate that PF blocks the migration and invasion of breast cancer cells by repressing EMT under hypoxic conditions. PF also significantly attenuated the hypoxia-induced increase in HIF-1? level. Furthermore, PF prevented hypoxia-induced expression of phosphorylated PI3K and Akt in MDA-MB-231 cells. In conclusion, PF prevented hypoxia-induced EMT in breast cancer cells by inhibiting HIF-1? expression via modulation of PI3K/Akt signaling pathway. This finding provides evidence that PF can serve as a therapeutic agent for the treatment of breast cancer. Twit Text FOAVip Paeoniflorin prevents hypoxia-induced epithelial-mesenchymal transition in human breast cancer cells ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=27175085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27175085 #FOAvip English Wikipedia <ref>{{Cite pmid|27175085 }}</ref> Paeoniflorin prevents hypoxia-induced epithelial-mesenchymal transition in human breast cancer cells #MMPMID27175085 Zhou Z ; Wang S ; Song C ; Hu Z Onco Targets Ther 2016[]; 9 (ä): 2511-8 PMID27175085 show ga Paeoniflorin (PF) is a monoterpene glycoside extracted from the root of Paeonia lactiflora Pall. Previous studies have demonstrated that PF inhibits the growth, invasion, and metastasis of tumors in vivo and in vitro. However, the effect of PF on hypoxia-induced epithelial-mesenchymal transition (EMT) in breast cancer cells remains unknown. Therefore, the objective of this study was to investigate the effect of PF on hypoxia-induced EMT in breast cancer cells, as well as characterize the underlying mechanism. The results presented in this study demonstrate that PF blocks the migration and invasion of breast cancer cells by repressing EMT under hypoxic conditions. PF also significantly attenuated the hypoxia-induced increase in HIF-1? level. Furthermore, PF prevented hypoxia-induced expression of phosphorylated PI3K and Akt in MDA-MB-231 cells. In conclusion, PF prevented hypoxia-induced EMT in breast cancer cells by inhibiting HIF-1? expression via modulation of PI3K/Akt signaling pathway. This finding provides evidence that PF can serve as a therapeutic agent for the treatment of breast cancer. äPaeoniflorin prevents hypoxia-induced epithelial-mesenchymal transitio(epmc).pdf DeepDyve Pubget Overpricing