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10.1016/j.celrep.2015.12.071 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.12.071 C4854207!4854207!26776520     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26776520&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 14 (4): 861-71 Nephropedia Template TP {{tp|p=26776520|t=2016. Sox9 positive progenitor cells play a key role in renal tubule epithelial regeneration in mice |pdf=|usr=}}{{26776520}} gab.com Text Sox9 positive progenitor cells play a key role in renal tubule epithelial regeneration in mice JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26776520 #FOAvip The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed high level of Sox9. In regenerating kidneys, Sox9 expression was induced early and 89% of proliferating cells were Sox9 positive. In vitro, Sox9 positive cells showed unlimited proliferation and multi-lineage differentiation capacity. Using an inducible Sox9 cre line and lineage tagging methods, we show that Sox9 positive cells can supply new daughter cells, contributing to the regeneration of proximal tubule, loop of Henle and distal tubule segments, but not to collecting duct and glomerular cells. Furthermore, inducible deletion of Sox9 resulted in reduced epithelial proliferation, more severe injury and fibrosis development. In summary, we demonstrate that in the kidney, Sox9 positive cells show progenitor-like properties in vitro, and contribute to epithelial regeneration following injury in vivo. Twit Text FOAVip Sox9 positive progenitor cells play a key role in renal tubule epithelial regeneration in mice ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26776520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26776520 #FOAvip English Wikipedia <ref>{{Cite pmid|26776520}}</ref> Sox9 positive progenitor cells play a key role in renal tubule epithelial regeneration in mice #MMPMID26776520 Kang HM; Huang S; Reidy K; Han SH; Chinga F; Susztak K Cell Rep 2016[Feb]; 14 (4): 861-71 PMID26776520show ga The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed high level of Sox9. In regenerating kidneys, Sox9 expression was induced early and 89% of proliferating cells were Sox9 positive. In vitro, Sox9 positive cells showed unlimited proliferation and multi-lineage differentiation capacity. Using an inducible Sox9 cre line and lineage tagging methods, we show that Sox9 positive cells can supply new daughter cells, contributing to the regeneration of proximal tubule, loop of Henle and distal tubule segments, but not to collecting duct and glomerular cells. Furthermore, inducible deletion of Sox9 resulted in reduced epithelial proliferation, more severe injury and fibrosis development. In summary, we demonstrate that in the kidney, Sox9 positive cells show progenitor-like properties in vitro, and contribute to epithelial regeneration following injury in vivo. äSox9 positive progenitor cells play a key role in renal tubule epithel(epmc).pdf DeepDyve Pubget Overpricing