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10.1136/bmjopen-2015-010114

http://scihub22266oqcxt.onion/10.1136/bmjopen-2015-010114
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C4853966!4853966!27126975
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suck abstract from ncbi


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pmid27126975      BMJ+Open 2016 ; 6 (4): ä
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  • Effect of FTY720 (fingolimod) on graft survival in renal transplant recipients: a systematic review protocol #MMPMID27126975
  • Gholamnezhadjafari R; Falak R; Tajik N; Aflatoonian R; Ali Keshtkar A; Rezaei A
  • BMJ Open 2016[]; 6 (4): ä PMID27126975show ga
  • Introduction: Studies have shown that FTY720 has inconsistent effects in kidney transplant recipients. Several review articles on FTY720 have been published, but most have focused on the mechanism of action of FTY720. Therefore, this review aims to evaluate and determine the beneficial and harmful effects of FTY720 therapy in kidney transplant recipients. Methods and analysis: We electronically searched the following databases: PubMed, Scopus, the Web of Sciences, EMBASE, Cochrane databases and the Cochrane Central Registry of Controlled Trials. Any clinical, randomised controlled trials relating to FTY720 for treating kidney transplant recipients were included without publication status or language restriction. Study selection, data extraction and assessment of study quality were performed independently by two researchers. Data were synthesised by either the fixed effects or the random effects model according to a heterogeneity test. If the extracted data were suitable for meta-analysis, STATA software was used to combine the relative risks for dichotomous outcomes, and the mean differences for continuous outcomes with 95% CIs were measured. Death, loss of function and incidence of acute kidney rejection were assessed as the primary outcomes. Renal graft function, malignancy, delayed graft function and infection were evaluated as secondary outcomes. Ethics/dissemination: This review does not require formal ethics approval because the data are not individualised. The resulting review article will be submitted for publication in a peer-reviewed journal. Trial registration number: CRD42015024648.
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