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2016 ; 6
(4
): e010114
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Effect of FTY720 (fingolimod) on graft survival in renal transplant recipients: a
systematic review protocol
#MMPMID27126975
Gholamnezhadjafari R
; Falak R
; Tajik N
; Aflatoonian R
; Ali Keshtkar A
; Rezaei A
BMJ Open
2016[Apr]; 6
(4
): e010114
PMID27126975
show ga
INTRODUCTION: Studies have shown that FTY720 has inconsistent effects in kidney
transplant recipients. Several review articles on FTY720 have been published, but
most have focused on the mechanism of action of FTY720. Therefore, this review
aims to evaluate and determine the beneficial and harmful effects of FTY720
therapy in kidney transplant recipients. METHODS AND ANALYSIS: We electronically
searched the following databases: PubMed, Scopus, the Web of Sciences, EMBASE,
Cochrane databases and the Cochrane Central Registry of Controlled Trials. Any
clinical, randomised controlled trials relating to FTY720 for treating kidney
transplant recipients were included without publication status or language
restriction. Study selection, data extraction and assessment of study quality
were performed independently by two researchers. Data were synthesised by either
the fixed effects or the random effects model according to a heterogeneity test.
If the extracted data were suitable for meta-analysis, STATA software was used to
combine the relative risks for dichotomous outcomes, and the mean differences for
continuous outcomes with 95% CIs were measured. Death, loss of function and
incidence of acute kidney rejection were assessed as the primary outcomes. Renal
graft function, malignancy, delayed graft function and infection were evaluated
as secondary outcomes. ETHICS/DISSEMINATION: This review does not require formal
ethics approval because the data are not individualised. The resulting review
article will be submitted for publication in a peer-reviewed journal. TRIAL
REGISTRATION NUMBER: CRD42015024648.
|*Kidney Transplantation
[MESH]
|Clinical Trials as Topic
[MESH]
|Fingolimod Hydrochloride/adverse effects/*therapeutic use
[MESH]
|Graft Rejection/*prevention & control
[MESH]
|Graft Survival/*drug effects
[MESH]
|Humans
[MESH]
|Immunosuppressive Agents/adverse effects/*therapeutic use
[MESH]