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2016 ; 6
(ä): 25467
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Evaluation of the diagnostic value of 64 simultaneously measured autoantibodies
for early detection of gastric cancer
#MMPMID27140836
Werner S
; Chen H
; Butt J
; Michel A
; Knebel P
; Holleczek B
; Zörnig I
; Eichmüller SB
; Jäger D
; Pawlita M
; Waterboer T
; Brenner H
Sci Rep
2016[May]; 6
(ä): 25467
PMID27140836
show ga
Autoantibodies against tumor-associated antigens (TAAs) have been suggested as
biomarkers for early detection of gastric cancer. However, studies that
systematically assess the diagnostic performance of a large number of
autoantibodies are rare. Here, we used bead-based multiplex serology to
simultaneously measure autoantibody responses against 64 candidate TAAs in serum
samples from 329 gastric cancer patients, 321 healthy controls and 124
participants with other diseases of the upper digestive tract. At 98%
specificity, sensitivities for the 64 tested autoantibodies ranged from 0-12% in
the training set and a combination of autoantibodies against five TAAs
(MAGEA4?+?CTAG1?+?TP53?+?ERBB2_C?+?SDCCAG8) was able to detect 32% of the gastric
cancer patients at a specificity of 87% in the validation set. Sensitivities for
early and late stage gastric cancers were similar, while chronic atrophic
gastritis, a precursor lesion of gastric cancer, was not detectable. However, the
5-marker combination also detected 26% of the esophageal cancer patients. In
conclusion, the tested autoantibodies and combinations alone did not reach
sufficient sensitivity for gastric cancer screening. Nevertheless, some
autoantibodies, such as anti-MAGEA4, anti-CTAG1 or anti-TP53 and their
combinations could possibly contribute to the development of cancer early
detection tests (not necessarily restricted to gastric cancer) when being
combined with other markers.
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