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10.3748/wjg.v22.i17.4287 http://scihub22266oqcxt.onion/10.3748/wjg.v22.i17.4287 C4853686!4853686!27158197     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Gastroenterol 2016 ; 22 (17): 4287-96 Nephropedia Template TP {{tp|p=27158197|t=2016. Precore/core region mutations of hepatitis B virus related to clinical severity |pdf=|usr=}}{{27158197}} gab.com Text Precore/core region mutations of hepatitis B virus related to clinical severity JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=27158197 #FOAvip Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due to cirrhosis and liver cancer. HBV mutations are primarily generated due both to a lack of proofreading capacity by HBV polymerase and to host immune pressure, which is a very important factor for predicting disease progression and therapeutic outcomes. Several types of HBV precore/core (preC/C) mutations have been described to date. The host immune response against T cells drives mutation in the preC/C region. Specifically, preC/C mutations in the MHC class II restricted region are more common than in other regions and are significantly related to hepatocellular carcinoma. Certain mutations, including preC G1896A, are also significantly related to HBeAg-negative chronic infection. This review article mainly focuses on the HBV preC/C mutations that are related to disease severity and on the HBeAg serostatus of chronically infected patients. Twit Text FOAVip Precore/core region mutations of hepatitis B virus related to clinical severity ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=27158197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27158197 #FOAvip English Wikipedia <ref>{{Cite pmid|27158197}}</ref> Precore/core region mutations of hepatitis B virus related to clinical severity #MMPMID27158197 Kim H; Lee SA; Do SY; Kim BJ World J Gastroenterol 2016[May]; 22 (17): 4287-96 PMID27158197show ga Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due to cirrhosis and liver cancer. HBV mutations are primarily generated due both to a lack of proofreading capacity by HBV polymerase and to host immune pressure, which is a very important factor for predicting disease progression and therapeutic outcomes. Several types of HBV precore/core (preC/C) mutations have been described to date. The host immune response against T cells drives mutation in the preC/C region. Specifically, preC/C mutations in the MHC class II restricted region are more common than in other regions and are significantly related to hepatocellular carcinoma. Certain mutations, including preC G1896A, are also significantly related to HBeAg-negative chronic infection. This review article mainly focuses on the HBV preC/C mutations that are related to disease severity and on the HBeAg serostatus of chronically infected patients. äPrecore/core region mutations of hepatitis B virus related to clinical(epmc).pdf DeepDyve Pubget Overpricing