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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Korean+Med+Sci
2016 ; 31
(6
): 909-14
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The Natural Course of Biopsy-Proven Isolated Microscopic Hematuria: a Single
Center Experience of 350 Patients
#MMPMID27247500
Lee HM
; Hyun JI
; Min JW
; Lee K
; Kim YK
; Choi EJ
; Song HC
J Korean Med Sci
2016[Jun]; 31
(6
): 909-14
PMID27247500
show ga
The increasing interest in healthcare and health screening events is revealing
additional cases of asymptomatic isolated microscopic hematuria (IMH). However, a
consensus of the evaluation and explanation of the IMH prognosis is controversial
among physicians. Here, we present the natural course of IMH together with the
pathological diagnosis and features to provide supportive data when approaching
patients with IMH. We retrospectively evaluated 350 patients with IMH who
underwent a renal biopsy between 2002 and 2011, and the pathological diagnosis
and chronic histopathological features (glomerulosclerosis, interstitial
fibrosis, and tubular atrophy) were reviewed. Deterioration of renal function was
examined during follow up. The patients with IMH were evaluated for a mean of 86
months. IgA nephropathy was the most common diagnosis in 164 patients (46.9%).
Chronic histopathological changes were observed in 166 (47.4%) but was not
correlated with proteinuria or a decline in renal function. Ten patients
developed proteinuria, and all of them had IgA nephropathy. Three patients
progressed to chronic kidney disease with an estimated glomerular filtration rate
< 60 mL/min/1.73 m(2) but none progressed to end stage renal disease. In
conclusion, IMH had a generally benign course during 7-years of observation,
although IgA nephropathy should be monitored if it progresses to proteinuria.
Future prospective randomized studies may help conclude the long-term prognosis
and lead to a consensus for managing IMH.