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10.1007/s13238-015-0241-6 http://scihub22266oqcxt.onion/10.1007/s13238-015-0241-6 C4853320!4853320!26946493     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+Cell 2016 ; 7 (5): 338-50 Nephropedia Template TP {{tp|p=26946493|t=2016. Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop |pdf=|usr=}}{{26946493}} gab.com Text Loss of I B kinase promotes myofibroblast transformation and senescence through activation of the ROS-TGF autocrine loop JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=26946493 #FOAvip Using forward and reverse genetics and global gene expression analyses, we explored the crosstalk between the I?B kinase ? (IKK?) and the transforming growth factor ? (TGF?) signaling pathways. We show that in vitro ablation of Ikk? in fibroblasts led to progressive ROS accumulation and TGF? activation, and ultimately accelerated cell migration, fibroblast-myofibroblast transformation and senescence. Mechanistically, the basal IKK? activity was required for anti-oxidant gene expression and redox homeostasis. Lacking this activity, IKK?-null cells showed ROS accumulation and activation of stress-sensitive transcription factor AP-1/c-Jun. AP-1/c-Jun activation led to up-regulation of the Tgf?2 promoter, which in turn further potentiated intracellular ROS through the induction of NADPH oxidase (NOX). These data suggest that by blocking the autocrine amplification of a ROS-TGF? loop IKK? plays a crucial role in the prevention of fibroblast-myofibroblast transformation and senescence.Electronic supplementary material: The online version of this article (doi:10.1007/s13238-015-0241-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip Loss of I B kinase promotes myofibroblast transformation and senescence through activation of the ROS-TGF autocrine loop ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=26946493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26946493 #FOAvip English Wikipedia <ref>{{Cite pmid|26946493}}</ref> Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop #MMPMID26946493 Chen L; Peng Z; Meng Q; Mongan M; Wang J; Sartor M; Chen J; Niu L; Medvedovic M; Kao W; Xia Y Protein Cell 2016[May]; 7 (5): 338-50 PMID26946493show ga Using forward and reverse genetics and global gene expression analyses, we explored the crosstalk between the I?B kinase ? (IKK?) and the transforming growth factor ? (TGF?) signaling pathways. We show that in vitro ablation of Ikk? in fibroblasts led to progressive ROS accumulation and TGF? activation, and ultimately accelerated cell migration, fibroblast-myofibroblast transformation and senescence. Mechanistically, the basal IKK? activity was required for anti-oxidant gene expression and redox homeostasis. Lacking this activity, IKK?-null cells showed ROS accumulation and activation of stress-sensitive transcription factor AP-1/c-Jun. AP-1/c-Jun activation led to up-regulation of the Tgf?2 promoter, which in turn further potentiated intracellular ROS through the induction of NADPH oxidase (NOX). These data suggest that by blocking the autocrine amplification of a ROS-TGF? loop IKK? plays a crucial role in the prevention of fibroblast-myofibroblast transformation and senescence.Electronic supplementary material: The online version of this article (doi:10.1007/s13238-015-0241-6) contains supplementary material, which is available to authorized users. äLoss of I?B kinase ? promotes myofibroblast transformation and senesce(epmc).pdf DeepDyve Pubget Overpricing